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Vol. 32 No. 8 (2020): Vol 32 Issue 8, 2020

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Synthesis, Characterization and Antioxidant Activity of Some New 3-(3-(Trifluoromethyl)phenyl)acrylic Acid Derived Hydrazide-Hydrazone Scaffolds

https://doi.org/10.14233/ajchem.2020.22825
Ramya Krishna Pallapati
Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar-522510, India
Baby Ramana Mutchu
Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar-522510, India
Umamaheswara Rao Vanga
Department of Botany & Microbiology, Acharya Nagarjuna University, Nagarjuna Nagar-522510, India
Ravi Varala
Scrips Pharma, Mallapur, Hyderabad-500076, India
Hari Babu Bollikolla
Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar-522510, India

Corresponding Author(s) : Hari Babu Bollikolla

dr.b.haribabu@gmail.com

Asian Journal of Chemistry, Vol. 32 No. 8 (2020): Vol 32 Issue 8, 2020

Abstract

Some new analogues of trifluoromethylphenyl acrylic acid scaffold derived hydrazide-hydrazones (4a-l) were produced by using various structurally divergent aromatic aldehydes. All the  hydrazones were obtained in moderate to good yields (64-78%) in methanol at a temperature of 45-65 °C. All the compounds were screened for antioxidant activity by DPPH method and the  compounds 4c, 4d, 4e and 4h were found to be showed maximum antioxidant activity among the synthesized compounds.

Keywords

Hydrazide-hydrazones 3-(3-(Trifluoromethyl)phenyl)acrylic acid Antioxidant activity Aldehydes
Pallapati, R. K. ., Mutchu, B. R. ., Rao Vanga, U. ., Varala, R. ., & Bollikolla, H. B. . (2020). Synthesis, Characterization and Antioxidant Activity of Some New 3-(3-(Trifluoromethyl)phenyl)acrylic Acid Derived Hydrazide-Hydrazone Scaffolds. Asian Journal of Chemistry, 32(8), 2099–2104. https://doi.org/10.14233/ajchem.2020.22825
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