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QSAR Studies of Flavonoids and Isoflavonoids with PTP1B: A Potential Pharmacological Target for the Treatment of Insulin Resistance

https://doi.org/10.14233/ajchem.2022.23784
Prangya Rath
Amity Institute of Environmental Sciences, Amity University Uttar Pradesh, Noida-201303, India
Anuj Ranjan
Amity Institute of Environmental Toxicology Safety and Management, Amity University Uttar Pradesh, Noida-201303, India
Abhishek Chauhan
Amity Institute of Environmental Toxicology Safety and Management, Amity University Uttar Pradesh, Noida-201303, India
Naval Kumar Verma
Ministry of Ayush, Ayush Bhawan, B Block, GPO Complex INA New Delhi-110023, India
Tanu Jindal
Amity Institute of Environmental Toxicology Safety and Management, Amity University Uttar Pradesh, Noida-201303, India

Corresponding Author(s) : Anuj Ranjan

aranjan@amity.edu

Asian Journal of Chemistry, Vol. 34 No. 4 (2022): Vol 34 Issue 4, 2022

Abstract

This study deals with designing and validating QSAR models generated for 45 flavonoids having PTP1B inhibition properties. Eight molecular descriptors/pharmacophoric features of each flavonoid along with their reported IC50 values against PTP1B were utilized to prepare training sets and generate models. It was developed by employing linear regression to calculate the predicted IC50 values. The generated models were validated using reported IC50 values of test sets. The correlation R2 values were observed to be in the following order, 92.45% (for an increasing hydrogen bond donor), 92.08% (for randomly sorting), 91.85% (for increasing molecular weight), 84.19% (for increasing hydrogen bond acceptor), 64.91% (for increasing TPSA), 53.90% (for increasing number of rotatable bonds) and 52.28% (for increasing log P); signifying the role of these pharmacophoric features while drug designing. Molecular docking of the flavonoids with the PTP1B active site revealed interactions with catalytic site and adjacent loops. The models would be beneficial for further studies for drug designing against PTP1B inhibition and therapeutic implications for treatment of insulin resistance.

Keywords

Insulin resistance QSAR Flavonoids PTP1B Inhibition Treatment
Rath, P., Ranjan, A., Chauhan, A., Kumar Verma, N., & Jindal, T. (2022). QSAR Studies of Flavonoids and Isoflavonoids with PTP1B: A Potential Pharmacological Target for the Treatment of Insulin Resistance. Asian Journal of Chemistry, 34(4), 1027–1038. https://doi.org/10.14233/ajchem.2022.23784
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