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Vol. 32 No. 8 (2020): Vol 32 Issue 8, 2020

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Tannic Acid Catalyzed Green Synthesis of Functionalized Chromeno-Pyrimidine-2,5-dione/thione Derivatives

https://doi.org/10.14233/ajchem.2020.22771
J. Puvithra
P.G. & Research Department of Chemistry, Rajeshwari Vedhachalam Government Arts College, Chengalpattu-603001, India
D. Parthiban
P.G. & Research Department of Chemistry, Rajeshwari Vedhachalam Government Arts College, Chengalpattu-603001, India
https://orcid.org/0000-0002-4254-5098

Corresponding Author(s) : D. Parthiban

nidhaksha@yahoo.co.in

Asian Journal of Chemistry, Vol. 32 No. 8 (2020): Vol 32 Issue 8, 2020

Abstract

Diversely functionalized chromeno-pyrimidine-2,5-dione/thione compounds were synthesized by cyclocondensation of 4-hydroxy coumarin, aldehydes and urea/thiourea using tannic acid  as a green catalyst and 1:1 (EtOH:H2O) as a green solvent. Different acids were screened for their catalytic activity of chromeno-pyrimidine-2,5-dione/thione derivatives. Tannic acid (10  mol%) was used as a suitable catalyst with increased catalytic activity. By utilizing this protocol, chromeno-pyrimidine scaffolds were prepared in acceptable to excellent yield without the use  of conventional volatile organic solvent and toxic metal catalyst. To our best of knowledge, this is the first report, in which tannic acid is utilized successfully as an eco-safe catalyst for  synthesis of fused pyrimidines. 

Keywords

Chromeno-pyrimidine-2,5-dione Tannic acid Nitrogen heterocycles 4-Hydroxy coumarins Multicomponent reaction
Puvithra, J. ., & Parthiban, D. . (2020). Tannic Acid Catalyzed Green Synthesis of Functionalized Chromeno-Pyrimidine-2,5-dione/thione Derivatives. Asian Journal of Chemistry, 32(8), 2067–2074. https://doi.org/10.14233/ajchem.2020.22771
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