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Vol. 34 No. 3 (2022): Vol 34 Issue 3, 2022

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CuI/TMEDA Catalyzed Solvent Free Homo-Coupling Reaction of Terminal Alkynes towards the Synthesis of Buta-1,3-diynes

https://doi.org/10.14233/ajchem.2022.23655
Amit Ranjan Panday
Department of Chemistry, Government Degree College, Kant, Shahjahanpur-242223, India ; Department of Applied Science and Humanities, Rajkiya Engineering College, Ambedkar Nagar-224122, India
Aditya Prakhar
Department of Chemistry, Government Degree College, Kant, Shahjahanpur-242223, India ; Department of Applied Science and Humanities, Rajkiya Engineering College, Ambedkar Nagar-224122, India
Durgesh Kumar Tiwari
Department of Chemistry, Government Degree College, Kant, Shahjahanpur-242223, India ; Department of Applied Science and Humanities, Rajkiya Engineering College, Ambedkar Nagar-224122, India
Devendra Pratap Mishra
Department of Applied Science and Humanities, Rajkiya Engineering College, Ambedkar Nagar-224122, India
Sudhir K. Sharma
Department of Chemistry, Government Degree College, Kant, Shahjahanpur-242223, India

Corresponding Author(s) : Sudhir K. Sharma

sudhirgdc19@gmail.com

Asian Journal of Chemistry, Vol. 34 No. 3 (2022): Vol 34 Issue 3, 2022

Abstract

An efficient method for the synthesis of buta-1,3-diynes have been developed via copper(I) catalyzed homocoupling reaction of terminal acetylenes in presence of CuI and tetramethylethylenediamine (TMEDA) at 100 ºC for 3.0 h under solvent-free conditions. This efficient methodology allowed the homocoupling of five terminal alkynes in moderate to excellent yields.

Keywords

Sonogashira reaction Cross-coupling Bisalkyne Alkynes Buta-1 3-diynes
Ranjan Panday, A., Prakhar, A., Kumar Tiwari, D., Pratap Mishra, D., & K. Sharma, S. (2022). CuI/TMEDA Catalyzed Solvent Free Homo-Coupling Reaction of Terminal Alkynes towards the Synthesis of Buta-1,3-diynes. Asian Journal of Chemistry, 34(3), 745–748. https://doi.org/10.14233/ajchem.2022.23655
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