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Vol. 32 No. 8 (2020): Vol 32 Issue 8, 2020

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Microwave-assisted Synthesis of 2-Substituted Naphtho[1,2-d][1,3]oxazoles by Reacting 1-Nitroso-2-naphthol with Allyl Bromides and Benzyl Bromides using FeCl3 as Catalyst

https://doi.org/10.14233/ajchem.2020.22745
N. Aljaar
Department of Chemistry, Hashemite University, P.O. Box 150459, Zarqa 13115, Jordan
https://orcid.org/0000-0002-3963-2238
S.M. Fraihat
Department of Chemistry, School of Science, The University of Jordan, 11942, Amman, Jordan
https://orcid.org/0000-0002-6159-6720
A. Alothman
Department of Medical Laboratory Science, Faculty of Allied Medical Sciences, Al-Ahliyya Amman University, Amman 19328, Jordan
N.A. Khalaf
Department of Pharmaceutical Science, Faculty of Pharmacy, Pharmacological and Diagnostic Research Center (PDRC), Al-Ahliyya Amman University, Amman 19328, Jordan

Corresponding Author(s) : N. Aljaar

nayyef@hu.edu.jo

Asian Journal of Chemistry, Vol. 32 No. 8 (2020): Vol 32 Issue 8, 2020

Abstract

Efficient and improved preparation of 2-substituted[1,2-d][1,3]oxazoles by the reaction of 1-nitroso-2-naphthol and allyl bromides, benzyl bromides under microwave condition utilizing FeCl3
as a catalyst with yield ranging from 32% to 72%. Reaction with bromo acetonitrile yields the corresponding 2-cyanonaphthoxazole with 58% yield.

Keywords

Microwave Allyl bromides Benzyl bromides 2-Substituted naphthoxazoles 1-Nitroso-2-naphthol
Aljaar, N. ., Fraihat, S. ., Alothman, A. ., & Khalaf, N. . (2020). Microwave-assisted Synthesis of 2-Substituted Naphtho[1,2-d][1,3]oxazoles by Reacting 1-Nitroso-2-naphthol with Allyl Bromides and Benzyl Bromides using FeCl3 as Catalyst. Asian Journal of Chemistry, 32(8), 2038–2042. https://doi.org/10.14233/ajchem.2020.22745
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