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Vol. 34 No. 3 (2022): Vol 34 Issue 3, 2022

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Studies on Ethanolic Extract of Brown Seaweed Turbinaria ornata from Coastal Area of Tamil Nadu: In vitro Antioxidant and Anticancer Properties

https://doi.org/10.14233/ajchem.2022.23594
S. Abul Kalam Azad
Department of Biochemistry, Rajah Serfoji Government College (Affiliated to Bharathidasan University, Tiruchirapalli), Thanjavur-613005, India
K. Jeyaprakash
Department of Biochemistry, Rajah Serfoji Government College (Affiliated to Bharathidasan University, Tiruchirapalli), Thanjavur-613005, India

Corresponding Author(s) : K. Jeyaprakash

jeypee5@gmail.com; jprsgc@gmail.com

Asian Journal of Chemistry, Vol. 34 No. 3 (2022): Vol 34 Issue 3, 2022

Abstract

Seaweeds are one of the most diverse bioreserves, including a wide range of bioactive compounds with various properties and functions. In present study, the antioxidant and anticancer activity of brown seaweed Turbinaria ornata was extracted using two different solvents like aqueous and ethanol. Higher concentrations of bioactive compounds were observed in ethanolic extract of T. ornata (EETO) in comparison to aqueous extract of T. ornata (AETO). The ethanolic extract showed potent antioxidant properties for DPPH and hydroxyl radical scavenging. The IC50 value of the ethanolic extract was found to be 48 and 50 μg/mL for DPPH and hydroxyl radical scavenging assay, respectively. Human breast adenocarcinoma (MCF-7) cells treated with different concentrations of the ethanolic extract showed a dose-dependent increase in cell inhibition. The LC50 value of the ethanolic extract was calculated to be 115.19 μg/mL and cell morphology was observed under an inverted phase-contrast microscope. As a result, based on the present findings, it is suggested that T. ornata extract might be a promising antioxidant and anticancer therapeutics.

Keywords

Turbinaria ornata Flavonoids Human breast adenocarcinoma cells Anticancer activity
Abul Kalam Azad, S., & Jeyaprakash, K. (2022). Studies on Ethanolic Extract of Brown Seaweed Turbinaria ornata from Coastal Area of Tamil Nadu: In vitro Antioxidant and Anticancer Properties. Asian Journal of Chemistry, 34(3), 668–672. https://doi.org/10.14233/ajchem.2022.23594
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