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Vol. 34 No. 3 (2022): Vol 34 Issue 3, 2022

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Thiazolopyrimidines: A Retrospective Study of Synthesis, Structure-Activity Relationship and Diverse Pharmacological Actions: A Review

https://doi.org/10.14233/ajchem.2022.23448
S. Aggarwal
Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra-136119, India
M. Devgun
Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra-136119, India
R. Narang
Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra-136119, India
S. Lal
Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra-136119, India
A.C. Rana
Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra-136119, India
R. Goyal
M.M. School of Pharmacy, Maharishi Markandeshwar University, Sadopur, Ambala-134007, India

Corresponding Author(s) : M. Devgun

manishdevgun@gmail.com

Asian Journal of Chemistry, Vol. 34 No. 3 (2022): Vol 34 Issue 3, 2022

Abstract

Thiazolopyrimidine is a nitrogen and sulphur containing heterocyclic aromatic molecule. The bicyclic compound is made by fusing two aromatic rings, thiazole and pyrimidine and replacing one carbon atom with nitrogen and sulphur. The current present work covers a wide range of methods for synthesizing thiazolopyrimidine and its derivatives using a variety of catalysts, solvent medium and microwave irradiation with a goal of achieving a high yield and rapid separation of the product. This article describes the evolution of thiazolopyrimidine as antimicrobial, antiviral, anti-Parkinson, anticancer, anti-inflammatory as well as its structure-activity relationship and potential mode of action for future research. It also includes a list of current patents filed/granted linked to various pharmacological activities in the previous few years.

Keywords

Thiazolopyrimidine Thiazolopyrimidine Synthesis Synthesis Pharmacological activities Pharmacological activities Docking targets Docking targets Mechanism of action Mechanism of action
Aggarwal, S., Devgun, M., Narang, R., Lal, S., Rana, A., & Goyal, R. (2022). Thiazolopyrimidines: A Retrospective Study of Synthesis, Structure-Activity Relationship and Diverse Pharmacological Actions: A Review. Asian Journal of Chemistry, 34(3), 519–530. https://doi.org/10.14233/ajchem.2022.23448
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