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Vol. 32 No. 8 (2020): Vol 32 Issue 8, 2020

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Efficient Synthesis of Novel Thiazole Substituted Pyrrolidine Derivatives and their Antimicrobial Evaluation

https://doi.org/10.14233/ajchem.2020.22772
Mahendra B. Bodake
Chemistry Research Centre, P.G. Department of Chemistry, K.T.H.M. College (Affiliated to Savitribai Phule Pune University, Pune), Gangapur Road, Nashik-422002, India
https://orcid.org/0000-0002-9007-2416
Ghanshyam R. Jadhav
Chemistry Research Centre, P.G. Department of Chemistry, K.T.H.M. College (Affiliated to Savitribai Phule Pune University, Pune), Gangapur Road, Nashik-422002, India
https://orcid.org/0000-0001-7993-3476
Vijay J. Medhane
1 Chemistry Research Centre, P.G. Department of Chemistry, K.T.H.M. College (Affiliated to Savitribai Phule Pune University, Pune), Gangapur Road, Nashik-422002, India 2 Department of Chemistry, S.V.K.T. College (Affiliated to Savitribai Phule Pune University, Pune), Deolali Camp, Nashik-422401, India
https://orcid.org/0000-0001-7623-7379
Avinash D. Bholay
P.G. Department of Microbiology, K.T.H.M. College (Affiliated to Savitribai Phule Pune University, Pune), Gangapur Road, Nashik-422002, India

Asian Journal of Chemistry, Vol. 32 No. 8 (2020): Vol 32 Issue 8, 2020

Abstract

A series of new molecules containing pyrrolidine and thiazole moiety (4a-l) were designed and synthesized. The structures of the synthesized compounds were characterized by IR, 1H NMR and mass spectral data. All the synthesized compounds were screened for their antibacterial activity against strains of bacteria as well as antifungal activity against fungal strains. Minimum inhibitory concentrations (MICs) of all the synthesized compounds were determined. The screening of title compounds revealed that most of the tested compounds showed moderate to good microbial inhibitions.

Keywords

Pyrrolidine Thiazole Antimicrobial activity
Bodake, M. B. ., Jadhav, G. R. ., Medhane, V. J. ., & Bholay, A. D. . (2020). Efficient Synthesis of Novel Thiazole Substituted Pyrrolidine Derivatives and their Antimicrobial Evaluation. Asian Journal of Chemistry, 32(8), 2007–2012. https://doi.org/10.14233/ajchem.2020.22772
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