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Vol. 34 No. 2 (2022): Vol 34 Issue 2

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Synthesis, Characterization and Biological Activity of ONO Donor Schiff Base and its Metal Complexes

https://doi.org/10.14233/ajchem.2022.23592
R. Nalini
Department of Studies in Chemistry, Bangalore University, Bengaluru-560056, India ; P.G. Department of Chemistry, Nrupathunga University (Government Science College), Bengaluru-560001, India
S.M. Basavarajaiah
P.G. Department of Chemistry, Vijaya College, R.V. Road, Bengaluru-560004, India
N.G. Yernale
Department of Chemistry, Guru Nanak First Grade College, Bidar-585403, India
K. Ramakrishna Reddy
Department of Studies in Chemistry, Bangalore University, Bengaluru-560056, India ; P.G. Department of Chemistry, Nrupathunga University (Government Science College), Bengaluru-560001, India

Corresponding Author(s) : K. Ramakrishna Reddy

rkrchem@gmail.com

Asian Journal of Chemistry, Vol. 34 No. 2 (2022): Vol 34 Issue 2

Abstract

A new Schiff base ligand (E)-2-((7-hydroxy-4-methyl-2-oxo-2H-chromen-8-yl)methylene)-N-(5-methyl-3-phenyl-1H-indol-2-yl)hydrazine carboxamide (L) (3) was synthesized by the reaction of N-(5-methyl-3-phenyl-1H-indol-2-yl)hydrazinecarboxamide (1) and 7-hydroxy-4-methyl-2-oxo-2H-chromene-8-carbaldehyde (2). The Cu(II), Co(II), Ni(II) and Zn(II) metal complexes (4a-d) were synthesized and its structural elucidation was done by different spectral techniques. The Schiff base (3) behaves as ONO donor ligand and forms the complexes of the sort [M(L)(Cl)(H2O)2] for Cu(II) (4a) and Zn(II) (4d) and [M(L)2] for Co(II) (4b) and Ni(II) (4c). Compounds (3) and (4a-d) were tested in vitro for antimicrobial action, cytotoxicity property against Artemia salina and anti-tuberculosis assay against Mycobacterium tuberculosis (ATCC 25177). The metal complexes showed very good biological activity.

Keywords

Coumarin Indole Cytotoxicity Schiff base Transition metal(II) complexes Antimicrobial activity Anti-tuberculosis
Nalini, R., Basavarajaiah, S., Yernale, N., & Ramakrishna Reddy, K. (2022). Synthesis, Characterization and Biological Activity of ONO Donor Schiff Base and its Metal Complexes. Asian Journal of Chemistry, 34(2), 389–394. https://doi.org/10.14233/ajchem.2022.23592
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