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Vol. 34 No. 2 (2022): Vol 34 Issue 2

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Bonding Ability of Isopthalic Acid-bis(thiosemicarbozone) to Manganese and Cobalt Metal Ions: Preparation, Spectral Investigation, Computational and in vitro Antipathogenic Screening

https://doi.org/10.14233/ajchem.2022.23508
S. Gautam
Department of Chemistry, Deshbandhu College, University of Delhi, Kalkaji, New Delhi-110019, India ; Department of Chemistry, Zakir Husain Delhi College, University of Delhi, JLN Marg, New Delhi-110002, India
P. Pipil
Department of Chemistry, Rajdhani College, University of Delhi, Raja Garden, Ring Road, New Delhi-110015, India
A. Kumar
Department of Chemistry, Dyal Singh College, University of Delhi, Lodhi Road, New Delhi-110003, India
ALKA
Department of Chemistry, Deshbandhu College, University of Delhi, Kalkaji, New Delhi-110019, India ; SRM-IST, Delhi-NCR Campus, Modinagar, Ghaziabad-201204, India
J. Singh
Department of Chemistry, Deshbandhu College, University of Delhi, Kalkaji, New Delhi-110019, India
RAVIKANT
Department of Chemistry, Zakir Husain Delhi College, University of Delhi, JLN Marg, New Delhi-110002, India
S. Singhal
Department of Chemistry, Deshbandhu College, University of Delhi, Kalkaji, New Delhi-110019, India
S.K. Sagar
Department of Zoology, Swami Shraddhanand College, University of Delhi, Alipur Road, Delhi-110036, India

Corresponding Author(s) : S. Gautam

seemachem.gautam@gmail.com

Asian Journal of Chemistry, Vol. 34 No. 2 (2022): Vol 34 Issue 2

Abstract

Manganese and cobalt complexes have been designed and prepared with a tetradentate ligand i.e. isopthalic acid-bis(thiosemicarbozone) (IPBT), which bind to metal ions via donor atoms present in ligand. Different spectroscopic techniques viz. nuclear magnetic resonance, infrared, mass, electronic spin resonance and analytical studies have been used to determine the chemical composition of synthesized IPBT and its Mn(II) and Co(II) complexes. The spectroscopic data exposed that IPBT behaves in a tetradentate (N2S2) mode by having ability to bind with metal ions through N2S2 atoms. An octahedral structure for manganese and cobalt complexes has been suggested on the basis of spectroscopic as well as analytical studies. The ligand (IPBT) and its metal(II) complexes have been screened to determine their antipathogenic activity against some selective microorganisms S. aureus, P. aeruginosa, E. coli, A. niger, M. phasolina and P. glomerata. In this experimental work, well diffusion and poisoned food techniques have been introduced for screening purpose and as standard drugs neomycin and chlorothalonil have been used. Data for antipathogenic screening exposed that metal complexes exerted higher activity towards all examined microbes (bacteria and fungi) even than ligand.

Keywords

Tetradentate ligand Isopthalic acid Metal complexes Antimicrobial screening Poisoned food method
Gautam, S., Pipil, P., Kumar, A., ALKA, ., Singh, J., RAVIKANT, ., … Sagar, S. (2022). Bonding Ability of Isopthalic Acid-bis(thiosemicarbozone) to Manganese and Cobalt Metal Ions: Preparation, Spectral Investigation, Computational and in vitro Antipathogenic Screening. Asian Journal of Chemistry, 34(2), 311–318. https://doi.org/10.14233/ajchem.2022.23508
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