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Vol. 29 No. 3 (2017): Vol 29 Issue 3

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Synthesis of 4-Chloro-5,6-dihydro-2H-pyran Derivatives by NbCl5 Mediated Cyclization of Epoxides with Homopropargylic Alcohols

https://doi.org/10.14233/ajchem.2017.20277
N. Maruthi Raju
Custom Pharmaceutical Services, Dr. Reddy’s Laboratories Limited, Bollaram Road, Miyapur, Hyderabad-500 049, India; Department of Organic Chemistry, Foods, Drugs and Water, Andhra University, Visakhapatnam-530 003, India
K. Rajasekhar
Ragas Pharmaceuticals Private Limited (OPC), IDA Cherlapally, Hyderabad-500 051, India
J. Moses Babu
Custom Pharmaceutical Services, Dr. Reddy’s Laboratories Limited, Bollaram Road, Miyapur, Hyderabad-500 049, India
B. Venkateswara Rao
Department of Organic Chemistry, Foods, Drugs and Water, Andhra University, Visakhapatnam-530 003, India

Corresponding Author(s) : K. Rajasekhar

koorella.rajasekhar@gmail.com

Asian Journal of Chemistry, Vol. 29 No. 3 (2017): Vol 29 Issue 3

Abstract

Epoxides undergoes cyclization with homopropargylic alcohols in the presence of niobium pentachloride under mild condition to afford the corresponding dihydropyran derivatives in good yield.

Keywords

Epoxides Homopropargylic alcohols Dihydropyrans Niobium pentachloride
Raju, N. M., Rajasekhar, K., Babu, J. M., & Rao, B. V. (2016). Synthesis of 4-Chloro-5,6-dihydro-2H-pyran Derivatives by NbCl5 Mediated Cyclization of Epoxides with Homopropargylic Alcohols. Asian Journal of Chemistry, 29(3), 614–616. https://doi.org/10.14233/ajchem.2017.20277
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