Synthesis and Spectral Studies of Piprazine Schiff Base Lanthanide(III) Complexes and their Microbial and Anticancer Activity

Abstract

A novel Schiff base ligand has been synthesized by the condensation reaction of 1-(2-amino ethyl)piprazine with o-vanillin in methanol solution. Using lanthanide(III) metal ions (Ln³⁺ = La³⁺, Ce³⁺, Pr³⁺, Nd³⁺, Sm³⁺ and Gd³⁺) in methanol, six complexes of piprazine Schiff base were synthesized. All the lanthanide(III) complexes were characterized by IR, UV, NMR, TG-DTA, X-ray diffraction analysis and photoluminence. According to the spectral analysis piprazine act as a bidentate monobasic donor coordinating through the azomethine nitrogen and a phenyl oxygen atom. Antimicrobial studies of the synthesized compounds were evaluated and reported. Anticancer activities were also studied towards the human breast cancer cell line (MCF-7).