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A Review on Synthesis and Pharmacological Activities of Piracetam and its Derivatives

https://doi.org/10.14233/ajchem.2022.23357
Nidhi Dhama
Department of Pharmaceutical Chemistry, Kharvel Subharti College of Pharmacy, Swami Vivekanand Subharti University, Meerut-250005,, India ; Department of Pharmaceutical chemistry, K.R. Mangalam University, Sohna Road, Sohna Rural-122103, India
Sucheta
Department of Pharmaceutical chemistry, K.R. Mangalam University, Sohna Road, Sohna Rural-122103, India ;
Aadesh KUMAR
Department of Pharmaceutical Chemistry, Kharvel Subharti College of Pharmacy, Swami Vivekanand Subharti University, Meerut-250005,, India
Vikrant Verma
Department of Pharmaceutical Chemistry, Kharvel Subharti College of Pharmacy, Swami Vivekanand Subharti University, Meerut-250005,, India
Sunil Kumar
Department of Pharmaceutical chemistry, K.R. Mangalam University, Sohna Road, Sohna Rural-122103, India

Corresponding Author(s) : Nidhi Dhama

nidhi.dhama.9693@gmail.com

Asian Journal of Chemistry, Vol. 34 No. 1 (2022): Vol 34 Issue 1, 2022

Abstract

Piracetam is generally utilized as a nootropic drug, which is normally used in the treatment of CNS disorders. Piracetam is a cyclic compound and a derivative of γ-aminobutyric acid and improves learning, memory, brain metabolism, and ability. This drug belongs to the racetams group with the chemical name 2-oxo-1-pyrrolidine acetamide. The emphasis of this review article is to highlight different biological activities associated with piracetam and also some of its synthetic methodologies. Promising effects have been achieved in the management and treatment of several diseases for example alcoholism, Raynaud’s phenomenon, deep vein thrombosis and brain injury.

Keywords

Cognitive disorders Piracetam GABA derivatives CNS disorder Nootropic drug
Dhama, N., Sucheta, ., KUMAR, A., Verma, V., & Kumar, S. (2021). A Review on Synthesis and Pharmacological Activities of Piracetam and its Derivatives. Asian Journal of Chemistry, 34(1), 1–8. https://doi.org/10.14233/ajchem.2022.23357
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