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Vol. 33 No. 12 (2021): Vol 33 Issue 12, 2021

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Synthetic Approach, Structural Performance and in vitro Antibacterial Activity: Nitrogen and Oxygen Donor Atoms containing Bidentate Schiff Base Ligand and its Mononuclear Complexation with Co(II) and Cu(II) Metal Ions

https://doi.org/10.14233/ajchem.2021.23491
Ravikant
Department of Chemistry, Zakir Husain Delhi College, University of Delhi, J.L.N. Marg, New Delhi-110002, India
S. Gautam
Department of Chemistry, Deshbandhu College, University of Delhi, Kalkaji, New Delhi-110019, India
H.K. Rajor
Department of Chemistry, Ramjas College, University of Delhi, New Delhi-110007, India
P. Pipil
Department of Chemistry, Rajdhani College, University of Delhi, Raja Garden, Ring Road, New Delhi-110015, India
J. Singh
Department of Chemistry, Deshbandhu College, University of Delhi, Kalkaji, New Delhi-110019, India
S. Singhal
Department of Chemistry, Deshbandhu College, University of Delhi, Kalkaji, New Delhi-110019, India
S.K. Sagar
Department of Zoology, Swami Shraddhanand College, University of Delhi, Alipur Road, Delhi-110036, India

Corresponding Author(s) : Ravikant

raviluvkant@gmail.com

Asian Journal of Chemistry, Vol. 33 No. 12 (2021): Vol 33 Issue 12, 2021

Abstract

A synthetic approach has been designed and followed for the synthesis of new bidentate Schiff base ligand 2-acetylthiophenenicotinic hydrazone (L) (which possessed nitrogen and oxygen donor atoms) and its Co(II) and Cu(II) mononuclear complexes. All the compounds were examined IR, 1H NMR, mass, EPR, conductivity, elemental analysis, etc. Octahedral geometry has been assigned to all synthesized compounds on the basis of magnetic, IR and electronic spectral analysis. In vitro activity i.e. antibacterial (E. coli and P. aeruginosa) and antifungal (A. niger, M. phasolina and P. glomerata) had been examined for these compounds following well diffusion and poisoned food methods, respectively. During the performance of antifungal activity, antifungal agent was incorporated into the molten agar at various concentrations and mixed well. After performance of in vitro activity, it has been resulted out that metal(II) complexes exhibited remarkable activity than free ligand but less active compared to the standard drugs.

Keywords

Schiff base Acetylthiophenenicotinic hydrazone Metal(II) complex Well diffusion method Poisoned food method
Ravikant, ., Gautam, S., Rajor, H., Pipil, P., Singh, J., Singhal, S., & Sagar, S. (2021). Synthetic Approach, Structural Performance and in vitro Antibacterial Activity: Nitrogen and Oxygen Donor Atoms containing Bidentate Schiff Base Ligand and its Mononuclear Complexation with Co(II) and Cu(II) Metal Ions. Asian Journal of Chemistry, 33(12), 3047–3055. https://doi.org/10.14233/ajchem.2021.23491
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