Copyright (c) 2021 AJC
This work is licensed under a Creative Commons Attribution 4.0 International License.
Synthesis, Molecular Docking and Evaluation of Library of 3-Mercapto-1,2,4-Triazole Derivatives as Antimicrobial Agents
Corresponding Author(s) : Santosh L. Gaonkar
Asian Journal of Chemistry,
Vol. 33 No. 12 (2021): Vol 33 Issue 12, 2021
Abstract
Due to the increasing microbial resistance to antibacterial and antifungal drugs, the development of new antimicrobial agents is an urgent priority. In search of newer antimicrobial agents, a series of 4,5-disubstituted-3-mercapto-1,2,4-triazole derivatives were synthesized from aromatic acids and substituted isothiocyanates. The in silico study was performed to study the binding interactions of the synthesized compounds with the active pocket of CYP51. Among the synthesized 3-mercapto-triazole derivatives, compounds 6r, 6s and 6u exhibited promising antimicrobial activity comparable to standard drugs. The results suggested that the structural modification to 3-mercapto-1,2,4-triazole derivatives could lead to promising antimicrobial scaffolds.
Keywords
Download Citation
Endnote/Zotero/Mendeley (RIS)BibTeX