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Synthesis, Characterization, Molecular Modeling, Antimicrobial and DNA Binding Studies of Cobalt(II) Complexes of 2,3-(Diimino-4'-antipyrinyl)butane with Varying Counter Ions

https://doi.org/10.14233/ajchem.2017.20344
B.N. Anila
Department of Chemistry, Government College Kottayam, Kottayam-686 013, India
M.K. Muraleedharan Nair
Department of Chemistry, Maharajas College, Ernakulam-682 011, India
Jisha Sreedharan
School of Chemical Sciences, Mahatma Gandhi University, Kottayam-686 560, India
V.P. Sylas
School of Environmental Sciences, Mahatma Gandhi University, Kottayam-686 560, India

Corresponding Author(s) : B.N. Anila

bnanila@gmail.com

Asian Journal of Chemistry, Vol. 29 No. 3 (2017): Vol 29 Issue 3

Abstract

The synthesis and characterization of perchlorate, nitrate, chloride, bromide and iodide complexes of cobalt(II) with a new Schiff base ligand 2,3-(diimino-4¢-antipyrinyl)butane prepared from 4-aminoantipyrine and 2,3-butanedione have been done by elemental analysis, electrical conductance in non-aqueous solvents, infrared and electronic and 1H NMR spectra as well as thermogravimetry. The UV-visible, magnetic susceptibility and ESR spectral data suggest an octahedral geometry around the central metal ion in chloro and bromo complexes and a tetrahedral geometry around the central metal ion for perchlorate, nitrate and iodide complexes. The molecular modeling of the proposed structure is in agreement with the above mentioned structure. Biological screening analyses of the ligands and the cobalt(II) complexes reveals that the Schiff base and its cobalt(II) complexes show significant activity against microorganisms. Binding studies of Co(II) complexes with calf thymus DNA (CT DNA) were studied by spectral methods such as absorption spectroscopy through the ethidium bromide (EB) displacement technique and viscosity measurements. The results obtained indicate that the complexes bind to DNA via intercalation.

Keywords

2,3-(Diimino-4¢-antipyrinyl)butane Antipyrine Cobalt(II) complexes Antimicrobial studies DNA binding studies
Anila, B., Muraleedharan Nair, M., Sreedharan, J., & Sylas, V. (2016). Synthesis, Characterization, Molecular Modeling, Antimicrobial and DNA Binding Studies of Cobalt(II) Complexes of 2,3-(Diimino-4’-antipyrinyl)butane with Varying Counter Ions. Asian Journal of Chemistry, 29(3), 691–702. https://doi.org/10.14233/ajchem.2017.20344
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