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Vol. 33 No. 10 (2021): Vol 33 Issue 10, 2021

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Mechanism of Antiangiogenic and Antioxidant Activity of Newly Synthesized CAMBA in Ehrlich Ascites Carcinoma-Bearing Mice

https://doi.org/10.14233/ajchem.2021.23310
Nada I. Abou-Taleb
Department of Radiology and Medical Imaging, Faculty of Applied Medical Science, October 6 University, 6th of October City, Egypt
Ola A. Elblasy
Department of Radiology and Medical Imaging, Faculty of Applied Medical Science, October 6 University, 6th of October City, Egypt
Esraa A. Elbesoumy
Department of Radiology and Medical Imaging, Faculty of Applied Medical Science, October 6 University, 6th of October City, Egypt
Haidy I. Basuny
Department of Radiology and Medical Imaging, Faculty of Applied Medical Science, October 6 University, 6th of October City, Egypt
Esraa A. Elhamadi
Department of Radiology and Medical Imaging, Faculty of Applied Medical Science, October 6 University, 6th of October City, Egypt
Mohamed S. Nasr eldin
Department of Radiology and Medical Imaging, Faculty of Applied Medical Science, October 6 University, 6th of October City, Egypt
Ahmed A. Emara
Department of Radiology and Medical Imaging, Faculty of Applied Medical Science, October 6 University, 6th of October City, Egypt
Ali A. Ali
Vice President of Post Graduate Studies, October 6 University, 6th of October City, Egypt
Mohamed A. Salem
Department of Organic Chemistry, Faculty of Pharmacy, October 6 University, 6th of October City, Egypt
Fakher M. Ahmed
Department of Organic Chemistry, Faculty of Pharmacy, October 6 University, 6th of October City, Egypt
Mohammed A. Hussein
Department of Biochemistry, Faculty of Applied Medical Science, October 6 University, 6th of October City, Egypt

Corresponding Author(s) : Mohammed A. Hussein

prof.husseinma@o6u.edu.eg

Asian Journal of Chemistry, Vol. 33 No. 10 (2021): Vol 33 Issue 10, 2021

Abstract

The aim of present study was to evaluate antiangiogenic activity of newly synthesized caffeic acid methyl benzoate amide (CAMBA) in EAC-bearing mice. The IC50 value of CAMBA against the Hep-G2 liver carcinoma cell line was calculated. Adult albino mice weighing 25 ± 5 g was used to assess the antiangiogenic activity of CAMBA (25 and 50 mg/k.b.w.) in EAC-bearing mice. IC50 CAMBA against the Hep-G2 cell line equals 52.8 μg/mL. The daily oral administration of CAMBA at concentrations of 25 and 50 mg/kg.b.w. for 30 days to EAC-bearing mice resulted in a significant improvement in tumor volume and tumor weight, ALT, AST, ALP, MMP-2 and -9, TNF-α, NOx, TBARs, GSH, CAT, SOD, GPx and VEGF-C gene expression in EAC-bearing mice. Furthermore, CAMBA almost normalized these effects in liver histoarchitecture. The biochemical, histological and ultrasound examinations of our study suggested that CAMBA have antiangiogenic activity in EAC-bearing mice.

Keywords

CAMBA Hep-G2 liver carcinoma Antiangiogenic Ehrlich ascites carcinoma Anticancer activity
I. Abou-Taleb, N., A. Elblasy, O., A. Elbesoumy, E., I. Basuny, H., A. Elhamadi, E., S. Nasr eldin, M., … A. Hussein, M. (2021). Mechanism of Antiangiogenic and Antioxidant Activity of Newly Synthesized CAMBA in Ehrlich Ascites Carcinoma-Bearing Mice. Asian Journal of Chemistry, 33(10), 2465–2471. https://doi.org/10.14233/ajchem.2021.23310
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References
  1. F. Bray, J. Ferlay, I. Soerjomataram, R.L. Siegel, L.A. Torre and A. Jemal, CA Cancer J. Clin., 68, 394 (2018); https://doi.org/10.3322/caac.21492
  2. Z. Xiao, G.E. Lester, Y. Luo and Q. Wang, J. Agric. Food Chem., 60, 7644 (2012); https://doi.org/10.1021/jf300459b
  3. S.A. Mir, M.A. Shah and M.M. Mir, Crit. Rev. Food Sci. Nutr., 13, 2730 (2017); https://doi.org/10.1080/10408398.2016.1144557
  4. A.J. Young and G.M. Lowe, Arch. Biochem. Biophys., 385, 20 (2001); https://doi.org/10.1006/abbi.2000.2149
  5. L. Chen, J.Y. Hu and S.Q. Wang, J. Am. Acad. Dermatol., 23, 231 (2012); https://doi.org/10.1016/j.jaad.2012.02.009
  6. T.A. Yap, A. Omlin and J.S. de Bono, J. Clin. Oncol., 31, 1592 (2013); https://doi.org/10.1200/JCO.2011.37.6418
  7. W. Guo, E. Kong and M. Meydani, Nutr. Cancer, 61, 807 (2009); https://doi.org/10.1080/01635580903285098
  8. X.-J. Chao, Z.-W. Chen, A.-M. Liu, X.-X. He, S.-G. Wang, Y.-T. Wang, P.-Q. Liu, C. Ramassamy, S.-H. Mak, W. Cui, A.-N. Kong, Z.-L. Yu, Y.-F. Han and R.-B. Pi, CNS Neurosci. Ther., 20, 840 (2014); https://doi.org/10.1111/cns.12286
  9. T. Wan, Z. Wang, Y. Luo, Y. Zhang, W. He, Y. Mei, J. Xue, M. Li, H. Pan, W. Li, Q. Wang and Y. Huang, Oxid. Med. Cell Longev., 2019, 8239642 (2019); https://doi.org/10.1155/2019/8239642
  10. R. Rezaei, K. Baghaei, S.M. Hashemi, M.R. Zali, H. Ghanbarian and D. Amani, Front. Med., 8, 619939 (2021); https://doi.org/10.3389/fmed.2021.619939
  11. H.F. Liao, Y.Y. Chen, J.J. Liu, M.L. Hsu, H.J. Shieh, H.J. Liao, C.J. Shieh, M.S. Shiao and Y.J. Chen, J. Agric. Food Chem., 51, 7907 (2003); https://doi.org/10.1021/jf034729d
  12. M.A. Hussein and N.A. Gobba, Med. Chem., 3, 286 (2013); https://doi.org/10.4172/2161-0444.1000153
  13. G.-W. Rao, G.-J. Xu, J. Wang, X.-L. Jiang and H.-B. Li, Chem. Med. Chem., 8, 928 (2013); https://doi.org/10.1002/cmdc.201300120
  14. A.M. Alafeefy, S.I. Alqasoumi, A.E. Ashour and M.M. Alshebly, J. Enzyme Inhib. Med. Chem., 28, 375 (2013); https://doi.org/10.3109/14756366.2012.668541
  15. M.M. Ghorab, Z.H. Ismail and M. Abdalla, Arzneimittelforschung, 60, 87 (2010); https://doi.org/10.1055/s-0031-1296254
  16. V.B. Konkimalla, V.L. Suhas, N.R. Chandra, E. Gebhart and T. Efferth, Expert Rev. Anticancer Ther., 7, 317 (2007); https://doi.org/10.1586/14737140.7.3.317
  17. H.A.E.H. El Gizawy, M.A. Hussein and E. Abdel-Sattar, Pharm. Biol., 57, 485 (2019); https://doi.org/10.1080/13880209.2019.1643378
  18. M.A. Hussein, Med. Chem. Res., 21, 1876 (2012); https://doi.org/10.1007/s00044-011-9707-0
  19. M.A. Hussein, Med Chem Res., 22, 4641 (2013); https://doi.org/10.1007/s00044-013-0468-9
  20. C.N. Kavitha, K.D. Raja and S.K. Rao, J. Cancer Res. Ther., 17, 491 (2021); https://doi.org/10.4103/jcrt.JCRT_454_19
  21. B. Choudhury, R. Kandimalla, R. Bharali, J. Monisha, A.B. Kunnumakara, K. Kalita and J. Kotoky, Front. Pharmacol., 7, 3 (2016); https://doi.org/10.3389/fphar.2016.00003
  22. G. Schumann and R. Klauke, Clin. Chim. Acta, 327, 69 (2003); https://doi.org/10.1016/s0009-8981(02)00341-8
  23. A.L. Caúla, R. Lira-Junior, E.M. Tinoco and R.G. Fischer, J. Periodontal Res., 50, 793 (2015); https://doi.org/10.1111/jre.12266
  24. J.G. Lee, S. Dahi, R. Mahimkar, N.L. Tulloch, M.A. Alfonso-Jaume, D.H. Lovett and R. Sarkar, Proc. Natl. Acad. Sci. USA, 102, 16345 (2005); https://doi.org/10.1073/pnas.0508085102
  25. H.E. Turner, Z. Nagy, M.M. Esiri, A. Harris and J.A.H. Wass, J. Clin. Endocrinol. Metab., 85, 2931 (2000); https://doi.org/10.1210/jcem.85.8.6754
  26. F. Feriyani, H. Maulanza, R.R. Lubis, U. Balqis and D. Darmawi, Scient. World J., 2021, 6617292 (2021); https://doi.org/10.1155/2021/6617292
  27. A. Bhattacharjee, A. Basu, J. Biswas, T. Sen and S. Bhattacharya, Mol. Cell Biochem., 424, 13 (2017); https://doi.org/10.1007/s11010-016-2839-2
  28. K.M. Miranda, M.G. Espey and D.A. Wink, Nitric Oxide, 5, 62 (2001); https://doi.org/10.1006/niox.2000.0319
  29. M.E. Dominiecki, G.L. Beatty, Z.K. Pan, P. Neeson and Y. Paterson, Cancer Immunol. Immunother., 54, 477 (2005); https://doi.org/10.1007/s00262-004-0610-0
  30. M. Schulz, S. Iwersen-Bergmann, H. Andresen and A. Schmoldt, Crit. Care, 16, R136 (2012); https://doi.org/10.1186/cc11441
  31. M.H. Hadwan and S.K. Ali, Anal. Biochem., 542, 29 (2018); https://doi.org/10.1016/j.ab.2017.11.013
  32. T. Ramasarma, A.V. Rao, M.M. Devi, R.V. Omkumar, K.S. Bhagyashree and S.V. Bhat, Mol. Cell Biochem., 400, 277 (2015); https://doi.org/10.1007/s11010-014-2284-z
  33. Y. Wang, Y. Liu, F. Ding, X. Zhu, L. Yang, P. Zou, H. Rao, Q. Zhao and X. Wang, Anal. Bioanal. Chem., 410, 4805 (2018); https://doi.org/10.1007/s00216-018-1117-4
  34. D. Feng, W.H. Ling and R.D. Duan, Inflamm. Res., 59, 115 (2010); https://doi.org/10.1007/s00011-009-0077-8
  35. H. Yamaguchi and J. Shen, Eds.: K. McCall and C. Klein, Histological Analysis of Neurodegeneration in the Mouse Brain; Necrosis, Methods in Molecular Biology, Humana Press, Totowa, NJ, vol. 1004 (2013).
  36. A. Aragón-Muriel, Y. Liscano, Y. Upegui, S.M. Robledo, M.T. RamírezApan, D. Morales-Morales, J. Oñate-Garzón and D. Polo-Cerón, Antibiotics, 10, 728 (2021); https://doi.org/10.3390/antibiotics10060728
  37. A. Bala, B. Kar, P.K. Haldar, U.K. Mazumdar and S. Bera, J. Ethnopharmacol., 129, 131 (2010); https://doi.org/10.1016/j.jep.2010.03.010
  38. J. Kamarauskaite, R. Banienem, D. Trumbeckasm, A. Strazdauskasm and S. Trumbeckaitem, Antioxidants, 10, 747 (2021); https://doi.org/10.3390/antiox10050747
  39. H. Ozyurt, B. Ozyurt, K. Koca and S. Ozgocmen, Vascul. Pharmacol., 47, 108 (2007); https://doi.org/10.1016/j.vph.2007.04.008
  40. M.F. Tolba, H.A. Omar, S.S. Azab, A.E. Khalifa, A.B. Abdel-Naim and S.Z. Abdel-Rahman, Crit. Rev. Food Sci. Nutr., 56, 2183 (2016); https://doi.org/10.1080/10408398.2013.821967
  41. R.M. Borik and M.A. Hussein, Curr. Pharm. Biotechnol., (2021); https://doi.org/10.2174/1389201022666210601170650
  42. A.N. Choudhary, A. Kumar and V. Juyal, Med. Chem., 14, 172 (2015); https://doi.org/10.2174/1871523015666160114092144
  43. H. Göçer and I. Gülçin, Int. J. Food Sci. Nutr., 62, 821 (2011); https://doi.org/10.3109/09637486.2011.585963
  44. J. Fang, Q. Zhou, L.Z. Liu, C. Xia, X. Hu, X. Shi and B.-H. Jiang, Carcinogenesis, 28, 858 (2006); https://doi.org/10.1093/carcin/bgl205
  45. W. Fernando, H.P. Rupasinghe and D.W. Hoskin, Mini Rev. Med. Chem., 15, 479 (2015); https://doi.org/10.2174/1389557515666150414152933
  46. H.H. Cao, J.H. Chu, H.Y. Kwan, T. Su, H. Yu, C.-Y. Cheng, X.-Q. Fu, H. Guo, T. Li, A.K.-W. Tse, G.-X. Chou, H.-B. Mo and Z.-L. Yu, Sci. Rep., 6, 21731 (2016); https://doi.org/10.1038/srep21731
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