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Vol. 33 No. 10 (2021): Vol 33 Issue 10, 2021

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Synthesis of (E)-1-(2,4-Bis((1-phenyl-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-3-phenylprop-2-en-1-one Derivatives and their Antimicrobial Activity

https://doi.org/10.14233/ajchem.2021.23320
Nalla Umapathi
Department of Chemistry, Osmania University, Hyderabad-500007, India
Pochampally Jalapathi
Department of Chemistry, Osmania University, Hyderabad-500007, India
Matta Raghavender
Department of Chemistry, Osmania University, Hyderabad-500007, India
Bhookya Shankar
School of Chemistry, University of Hyderabad, A Central University, Hyderabad-500046, India

Corresponding Author(s) : Pochampally Jalapathi

pochampalli.ou.chemi@gmail.com

Asian Journal of Chemistry, Vol. 33 No. 10 (2021): Vol 33 Issue 10, 2021

Abstract

A new series of chalcone based bis 1,4-disubstituted 1,2,3-triazole heterocyclic molecules (6a-j) were synthesized via the reaction of 1-(2,4-bis((1-phenyl-1H-1,2,3-triazol-4-yl)methoxy)phenyl)ethanone (6a-e) with substituted benzaldehyde. All the molecules were characterized by IR, 1H and 13C NMR and MS spectra spectral data. Compounds 6a-j were evaluated for their antimicrobial effects using a broth disc diffusion method. The compounds were evaluated for their in vitro antimicrobial potential against Gram-positive (Micrococcus luteus, Methicillin-resistant Staphylococcus aureus, Bacillus subtilis and Bacillus cereus), Gram-negative (Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli and Proteus vulgaris) bacterial and fungal (Microsporum canis, Microsporum gypseum and Epidermophyton floccosum) strains by comparison of the reference drugs, zentamycin sulphate (antibacterial) and nystatin (antifungal). The screened compounds 6f, 6e, 6c and 6i were found to be the most active against all the tested bacterial and fungal strains.

Keywords

Chalcone Click chemistry approach Antimicrobial activity 1,2,3-Triazoles
Umapathi, N., Jalapathi, P., Raghavender, M., & Shankar, B. (2021). Synthesis of (E)-1-(2,4-Bis((1-phenyl-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-3-phenylprop-2-en-1-one Derivatives and their Antimicrobial Activity. Asian Journal of Chemistry, 33(10), 2341–2346. https://doi.org/10.14233/ajchem.2021.23320
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