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Vol. 33 No. 10 (2021): Vol 33 Issue 10, 2021

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Determination of Protonation Constants of Viral Inhibitor, Aurintricarboxylic Acid in SDS and CTAB Micellar Media: A Potentiometric Study

https://doi.org/10.14233/ajchem.2021.23318
K. Bhargavi
Department of Physical and Nuclear Chemistry & Chemical Oceanography, School of Chemistry, Andhra University, Visakhapatnam-530003, India
P. Shyamala
Department of Physical and Nuclear Chemistry & Chemical Oceanography, School of Chemistry, Andhra University, Visakhapatnam-530003, India
G. Nageswara Rao
Department of Inorganic and Analytical Chemistry, School of Chemistry, Andhra University, Visakhapatnam-530003, India

Corresponding Author(s) : P. Shyamala

shyamalapulipaka06@gmail.com

Asian Journal of Chemistry, Vol. 33 No. 10 (2021): Vol 33 Issue 10, 2021

Abstract

Protonation constants of a viral inhibitor, aurintricarboxylic acid were determined using potentiometric method of data acquisition followed by chemometric modelling methods of analysis in the presence of two different kinds of micellar media, CTAB, a cationic micelle and SDS, an anionic micelle. MINIQUAD75 program was used for the determination of the plausible species and their corresponding formation constants at 303 ± 0.1 K and 0.01 M ionic strength. Five formation constants were identified corresponding to five ionizable hydrogens. Species concentration distribution diagrams were generated using Origin software. Best-fit chemical models were selected on the basis of statistical parameters like standard deviation (SD), U (sum of the squares of the residuals in mass balance equations) and chi-square test. It was found that the formation constants are lower in CTAB micellar medium while there is no significant change in the presence of SDS compared to aqueous medium.

Keywords

Aurintricarboxylic Acid Sodium dodecyl sulfate Cetyltrimethylammonium bromide Protonation constant
Bhargavi, K., Shyamala, P., & Nageswara Rao, G. (2021). Determination of Protonation Constants of Viral Inhibitor, Aurintricarboxylic Acid in SDS and CTAB Micellar Media: A Potentiometric Study. Asian Journal of Chemistry, 33(10), 2301–2305. https://doi.org/10.14233/ajchem.2021.23318
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