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Microwave Promoted Y(NO3)3·6H2O Catalyzed Biginelli Synthesis of Dihydropyrimidin-2-ones

https://doi.org/10.14233/ajchem.2017.20219
A.A. Khan
Department of Chemistry, University of Gour Banga, Malda-732 103, India
K. Mitra
Department of Chemistry, University of Gour Banga, Malda-732 103, India
M.A. Mondal
Department of Chemistry, University of Gour Banga, Malda-732 103, India

Corresponding Author(s) : M.A. Mondal

mohabul.mondal@gmail.com

Asian Journal of Chemistry, Vol. 29 No. 3 (2017): Vol 29 Issue 3

Abstract

Biginelli synthesis of 3,4-dihydropyrimidinones from aldehydes, b-keto ester and urea using yttrium nitrate hexahydrate, as an efficient catalyst are demonstrated under microwave condition. This method offers significant advantages, such as high yields, short reaction times, easy isolation and mild reaction conditions. We have also investigated mechanism of Y(NO3)3 catalyzed 3,4-dihydropyrimidinones synthesis and identified the key intermediate benzal-bisurea by LC-MS.

Keywords

Biginelli reaction Yttrium nitrate Dihydropyrimidinones Multicomponent reaction Mechanistic study
Khan, A., Mitra, K., & Mondal, M. (2016). Microwave Promoted Y(NO3)3·6H2O Catalyzed Biginelli Synthesis of Dihydropyrimidin-2-ones. Asian Journal of Chemistry, 29(3), 529–534. https://doi.org/10.14233/ajchem.2017.20219
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