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Vol. 33 No. 9 (2021): Vol 33 Issue 9, 2021

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Detection of Non-nitro Compounds by Amplified Fluorescence Polymer (AFP): An Opportunity for Breath-Based Disease Diagnosis

https://doi.org/10.14233/ajchem.2021.23446
D. Sharath Kumar1
1Department of Chemistry, CMR Institute of Technology, Bengaluru-560037, India 2Department of Chemistry, School of Engineering and Technology, CMR University, Bengaluru-562149, India *Corresponding author: E-mail: phanikumar.p@cmrit.ac.in
H.S. Pallavi1
1Department of Chemistry, CMR Institute of Technology, Bengaluru-560037, India 2Department of Chemistry, School of Engineering and Technology, CMR University, Bengaluru-562149, India *Corresponding author: E-mail: phanikumar.p@cmrit.ac.in
Phani Kumar Pullela1
1Department of Chemistry, CMR Institute of Technology, Bengaluru-560037, India 2Department of Chemistry, School of Engineering and Technology, CMR University, Bengaluru-562149, India *Corresponding author: E-mail: phanikumar.p@cmrit.ac.in

Asian Journal of Chemistry, Vol. 33 No. 9 (2021): Vol 33 Issue 9, 2021

Abstract

Amplified fluorescence polymers (AFP) are a set of unique polymers known for their ability to detect trace nitro explosives. The prior knowledge in the AFP field indicates that the functional group variation on the polymer backbone is responsible for the selectivity of an analyte. The mechanism of analyte detection is believed that only compounds with nitro functional groups are detected by AFP. Usually, AFP functional groups varied to detect nitro compounds and the non-nitro compound detection and the mechanism of the AFP were not completely understood. In this work, the AFP polymer was kept constant and studied with 136 analytes with different functional groups for analyzing few non-nitro compounds. Among the 136 compounds analyzed, about fourteen have been detected by AFP. It was observed that most of the fourteen compounds were non-nitro compounds. The mechanism proposed originally for nitro compounds and associated hypothesises the existence of a parking space on the polymer backbone. Present study suggested that the possibility of only nitro compounds interacting with AFP due to the three-dimensional shape of the analyte as the detrimental factor. The discovery of non-nitro compound detection by AFP opens up the use of AFP for gas-phase disease volatile organic compound detection. Future studies of functional group variation on the AFP backbone in relation to the analyte detection could provide insights into the relation of analyte detection by AFP and the parameters to optimize for obtaining the selectivity and specificity.

Keywords

Amplified fluorescent polymer Volatile organic compounds Gas phases detection Quenching fluorescence.
Sharath Kumar1, D., Pallavi1, H., & Kumar Pullela1, P. (2021). Detection of Non-nitro Compounds by Amplified Fluorescence Polymer (AFP): An Opportunity for Breath-Based Disease Diagnosis. Asian Journal of Chemistry, 33(9), 2229–2236. https://doi.org/10.14233/ajchem.2021.23446
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References
  1. M.K. Nakhleh, H. Amal, R. Jeries, Y.Y. Broza, M. Aboud, A. Gharra, H. Ivgi, S. Khatib, S. Badarneh, L. Har-Shai, L. Glass-Marmor, I. Lejbkowicz, A. Miller, S. Badarny, R. Winer, J. Finberg, S. CohenKaminsky, F. Perros, D. Montani, B. Girerd, G. Garcia, G. Simonneau, F. Nakhoul, S. Baram, R. Salim, M. Hakim, M. Gruber, O. Ronen, T. Marshak, I. Doweck, O. Nativ, Z. Bahouth, D.Y. Shi, W. Zhang, Q.L. Hua, Y.Y. Pan, L. Tao, H. Liu, A. Karban, E. Koifman, T. Rainis, R. Skapars, A. Sivins, G. Ancans, I. Liepniece-Karele, I. Kikuste, I. Lasina, I. Tolmanis, D. Johnson, S.Z. Millstone, J. Fulton, J.W. Wells, L.H. Wilf, M. Humbert, M. Leja, N. Peled and H. Haick, ACS Nano, 11, 112 (2017); https://doi.org/10.1021/acsnano.6b04930
  2. K.H. Kim, S.A. Jahan and E. Kabir, TrAC Trends Analyt. Chem., 33, 1 (2012); https://doi.org/10.1016/j.trac.2011.09.013
  3. D.A.P. Daniel, K. Thangavel and R.S.C. Boss, A Review of Early Detection of Cancers Using Breath Analysis, International Conference on Pattern Recognition, Informatics Medical Engineering (PRIME), Salen, India, pp. 433-438 (2012); https://doi.org/10.1109/ICPRIME.2012.6208385
  4. P. Montuschi, M. Santonico, C. Mondino, G. Pennazza, G. Mantini, E. Martinelli, R. Capuano, G. Ciabattoni, R. Paolesse, C. Di Natale, P.J. Barnes and A. D'Amico, Chest, 137, 790 (2010); https://doi.org/10.1378/chest.09-1836
  5. A. Amann, B.D.L. Costello, W. Miekisch, J. Schubert, B. Buszewski, J. Pleil, N. Ratcliffe and T. Risby, J. Breath Res., 8, 034001 (2014); https://doi.org/10.1088/1752-7155/8/3/034001
  6. H. Amal, M. Leja, K. Funka, R. Skapars, A. Sivins, I. Liepniece-Karele, G. Ancans, I. Kikuste, I. Lasina and H. Haick, Gut, 65, 400 (2015); https://doi.org/10.1136/gutjnl-2014-308536
  7. B. de Lacy Costello, A. Amann, H. Al-Kateb, C. Flynn, W. Filipiak, T. Khalid, D. Osborne and N.M. Ratcliffe, J. Breath Res., 8, 014001 (2014); https://doi.org/10.1088/1752-7155/8/1/014001
  8. B.D.L. Costello, A. Amann, C. Flynn, W. Filipiak, T. Khalid, D. Osborne and N.M. Ratcliffe, J. Breath Res., 8, 014001 (2014); https://doi.org/10.1088/1752-7155/8/1/014001
  9. A. Bajtarevic, C. Ager, M. Pienz, M. Klieber, K. Schwarz, M. Ligor, T. Ligor, W. Filipiak, H. Denz, M. Fiegl, W. Hilbe, W. Weiss, P. Lukas, H. Jamnig, M. Hackl, A. Haidenberger, B. Buszewski, W. Miekisch, J. Schubert and A. Amann, BMC Cancer, 9, 348 (2009); https://doi.org/10.1186/1471-2407-9-348
  10. C. Turner, VOC Analysis by SIFT-MS, GC-MS, and Electronic Nose for Diagnosing and Monitoring Disease, Elsevier B.V. (2013).
  11. M.K. Nakhleh, Y.Y. Broza and H. Haick, Nanomedicine, 9, 1991 (2014); https://doi.org/10.2217/nnm.14.121
  12. U. Tisch and H. Haick, Arrays of Nanomaterial-Based Sensors for Breath Testing, Elsevier B.V. (2013).
  13. H. Amal, D.Y. Shi, R. Ionescu, W. Zhang, Q.L. Hua, Y.Y. Pan, L. Tao, H. Liu and H. Haick, Int. J. Cancer, 136, E614 (2015); https://doi.org/10.1002/ijc.29166
  14. K.K. Jain, Technologies for Discovery of Biomarkers, Springer Science +Business Media (2010).
  15. T.L. Andrew and T.M. Swager, J. Am. Chem. Soc., 129, 7254 (2007); https://doi.org/10.1021/ja071911c
  16. B. Xu, X. Wu, H. Li, H. Tong and L. Wang, Macromolecules, 44, 5089 (2011); https://doi.org/10.1021/ma201003f
  17. J.V. Goodpaster and V.L. McGuffin, Anal. Chem., 73, 2004 (2001); https://doi.org/10.1021/ac001347n
  18. D. Gopalakrishnan and W.R. Dichtel, J. Am. Chem. Soc., 135, 8357 (2013); https://doi.org/10.1021/ja402668e
  19. J.S. Caygill, F. Davis and S.P.J. Higson, Talanta, 88, 14 (2012); https://doi.org/10.1016/j.talanta.2011.11.043
  20. S.E. Zohora and N. Hundewale, Int. J. Soft Comput. Eng., 3, 405 (2013).
  21. D. James, S.M. Scott, Z. Ali and W.T. O’Hare, Mikrochim. Acta, 149, 1 (2005); https://doi.org/10.1007/s00604-004-0291-6
  22. M. Righettoni, A. Amann and S.E. Pratsinis, Mater. Today, 18, 163 (2015); https://doi.org/10.1016/j.mattod.2014.08.017
  23. M. Trojanowicz, TrAC Trends Analyt. Chem., 25, 480 (2006); https://doi.org/10.1016/j.trac.2005.11.008
  24. N.S. Ramgir, ISRN Nanomater., 2013, 1 (2013); https://doi.org/10.1155/2013/941581
  25. S. Li, J. Forensic Sci. Criminol., 1, 1 (2014).
  26. S. Singh, J. Hazard. Mater., 144, 15 (2007); https://doi.org/10.1016/j.jhazmat.2007.02.018
  27. S.W. Thomas, G.D. Joly and T.M. Swager, Chem. Rev., 107, 1339 (2007); https://doi.org/10.1021/cr0501339
  28. T.M. Swager and J.H. Wosnick, MRS Bull., 27, 446 (2002); https://doi.org/10.1557/mrs2002.143
  29. D.T. McQuade, A.E. Pullen and T.M. Swager, Chem. Rev., 100, 2537 (2000); https://doi.org/10.1021/cr9801014
  30. S.W. Thomas III and T.M. Swager, Eds.: M. Marshall and J.C. Oxley, Aspects of Explosives Detection, Elsevier B. V.: Amsterdam, pp. 203-222 (2009).
  31. T.M. Swager, Acc. Chem. Res., 41, 1181 (2008); https://doi.org/10.1021/ar800107v
  32. B. Esser and T.M. Swager, Angew. Chem. Int. Ed., 49, 8872 (2010); https://doi.org/10.1002/anie.201003899
  33. M. Fisher, J. Sikes and M. Prather, Proc. SPIE, 5403, 409 (2004); https://doi.org/10.1117/12.542900
  34. X. Sun, Y. Wang and Y. Lei, Chem. Soc. Rev., 44, 8019 (2015); https://doi.org/10.1039/C5CS00496A
  35. A. Amann, P. Mochalski, V. Ruzsanyi, Y.Y. Broza and H. Haick, J. Breath Res., 8, 16003 (2014); https://doi.org/10.1088/1752-7155/8/1/016003
  36. M.K. Nakhleh, R. Jeries, A. Gharra, A. Binder, Y.Y. Broza, M. Pascoe, K. Dheda and H. Haick, Eur. Respir. J., 43, 1522 (2014); https://doi.org/10.1183/09031936.00019114
  37. H. Haick, Y.Y. Broza, P. Mochalski, V. Ruzsanyi and A. Amann, Chem. Soc. Rev., 43, 1423 (2016); https://doi.org/10.1039/C3CS60329F
  38. M. Hakim, Y.Y. Broza, O. Barash, N. Peled, M. Phillips, A. Amann and H. Haick, Chem. Rev., 112, 5949 (2012); https://doi.org/10.1021/cr300174a
  39. S. Fischer, IEEE PLUS, 7, 213 (2007).
  40. G. Peng, M. Hakim, Y.Y. Broza, S. Billan, R. Abdah-Bortnyak, A. Kuten, U. Tisch and H. Haick, Br. J. Cancer, 103, 542 (2010); https://doi.org/10.1038/sj.bjc.6605810
  41. G. Peng, U. Tisch, O. Adams, M. Hakim, N. Shehada, Y.Y. Broza, S. Billan, R. Abdah-Bortnyak, A. Kuten and H. Haick, Nat. Nanotechnol., 4, 669 (2009); https://doi.org/10.1038/nnano.2009.235
  42. A. Kumar, J. Sinha, A.K. Majji, J. Raviprakash, S. Viswanathan, J.K. Paul, S.V. Mohan, S.K. Sanjeeva, S. Korrapati and C.B. Nair, Eds.: K.J. Vinoy, G.K. Ananthasuresh, R. Pratap, S.B. Krupanidhi, Micro Smart Devices Systems, Springer India: New Delhi, pp. 35-47 (2014).
  43. J.-S. Yang and T.M. Swager, J. Am. Chem. Soc., 120, 11864 (1998); https://doi.org/10.1021/ja982293q
  44. J.L. Novotney and W.R. Dichtel, ACS Macro Lett., 2, 423 (2013); https://doi.org/10.1021/mz4000249
  45. S.W. Thomas III, J.P. Amara, R.E. Bjork and T.M. Swager, Chem. Commun., 4572 (2005); https://doi.org/10.1039/b508408c
  46. S. Rochat and T.M. Swager, ACS Appl. Mater. Interfaces, 5, 4488 (2013); https://doi.org/10.1021/am400939w
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