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Vol. 33 No. 9 (2021): Vol 33 Issue 9, 2021

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Characterization, Molecular Docking, Antimicrobial and Anticancer Studies on 5-Bromo salicylaldehyde-furan-2-yl-methanamine Condensed Schiff Base Rare Earth Metal Complexes

https://doi.org/10.14233/ajchem.2021.23306
B. Preethi
Department of Chemistry, B.S. Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Chennai-600048, India
R. Jayaprakash
Department of Chemistry, School of Arts and Science, Aarupadai Veedu Institute of Technology Campus, Vinayaka Mission’s Research Foundation (Deemed to be University), Chennai-603104, India
S. Kutti Rani
Department of Chemistry, B.S. Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Chennai-600048, India
N. Vijayakumar
Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Chidambaram-608002, India

Corresponding Author(s) : S. Kutti Rani

skrani@crescent.education

Asian Journal of Chemistry, Vol. 33 No. 9 (2021): Vol 33 Issue 9, 2021

Abstract

This work described the synthesis and characterization of 1-(furan-2-yl) methanamine condensed with 5-bromo-2-hydroxybenzaldehyde Schiff base rare earth metal (Ln3+, Pr3+, Nd3+, Sm3+ and Eu3+) complexes. They were characterized using relevant spectral techniques and docked against microbial target proteins (1H9Z, 3ZBO) theoretically. The experimental antibacterial and anticancer activities (HeLa, MCF7) of these metal complexes were investigated for biological efficacy. Out of five metal complexes, Pr3+ complex exposed good biological efficacy result in both assays.

Keywords

Schiff base Rare-earth metals Antibacterial activity Anticancer activity
Preethi, B., Jayaprakash, R., Kutti Rani, S., & Vijayakumar, N. (2021). Characterization, Molecular Docking, Antimicrobial and Anticancer Studies on 5-Bromo salicylaldehyde-furan-2-yl-methanamine Condensed Schiff Base Rare Earth Metal Complexes. Asian Journal of Chemistry, 33(9), 2127–2134. https://doi.org/10.14233/ajchem.2021.23306
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