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Vol. 33 No. 9 (2021): Vol 33 Issue 9, 2021

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Antibacterial Activity against Enterococcus faecium, Enterococcus faecalis and Inhibitory Activity of Monoamine Oxidase A & B by Persea americana “Avocado” Seed Extracts

https://doi.org/10.14233/ajchem.2021.23294
N-D. Nogbou
Department of Microbiological Pathology, School of Medicine, Sefako Makgatho Health Sciences University, Pretoria, South Africa
Z.T. Mkhombo
Department of Chemistry, School of Science and Technology, Sefako Makgatho Health Sciences University, Pretoria, South Africa
M.T. Olivier
Department of Chemistry, School of Science and Technology, Sefako Makgatho Health Sciences University, Pretoria, South Africa
M.O. Ogunrombi
Department of Pharmacology & Therapeutics, School of Medicine, Sefako Makgatho Health Sciences University, Pretoria, South Africa
R.B. Maseko
Department of Chemistry, School of Science and Technology, Sefako Makgatho Health Sciences University, Pretoria, South Africa
A.M. Musyoki
Department of Microbiological Pathology, School of Medicine, Sefako Makgatho Health Sciences University, Pretoria, South Africa

Corresponding Author(s) : A.M. Musyoki

Andrew.musyoki@smu.ac.za

Asian Journal of Chemistry, Vol. 33 No. 9 (2021): Vol 33 Issue 9, 2021

Abstract

This study reported various Persia americana seed extracts for the presence and total content of phytochemicals, antibacterial activity and inhibitory activity against monoamine oxidase (MAO) A & B enzymes. Phytochemical studies showed that phenols, flavonoids and tannins were found in all the polar solvents. The highest antibacterial activity was exhibited against Gram-positive bacteria by acetone extract on Enterococcus faecium and methanol extract on Enterococcus faecalis. From the monoamine inhibition experiments, a significant inhibitory activity was observed from ethanolic extracts against MAO-A and from n-hexane extracts against MAO-B. This study demonstrates the antimicrobial activity of P. americana seed extracts against enterococci bacteria, E. faecium and E. faecalis. This finding offers hope of a potential new antibacterial compound in the treatment of these multidrug resistant bacteria.

Keywords

Antibacterial activity Persia americana Enterococcus faecalis Enterococcus faecium
Nogbou, N.-D., Mkhombo, Z., Olivier, M., Ogunrombi, M., Maseko, R., & Musyoki, A. (2021). Antibacterial Activity against Enterococcus faecium, Enterococcus faecalis and Inhibitory Activity of Monoamine Oxidase A & B by Persea americana “Avocado” Seed Extracts. Asian Journal of Chemistry, 33(9), 2093–2098. https://doi.org/10.14233/ajchem.2021.23294
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