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Development and Validation of Highly Sensitive Spectrophotometric Methods for Cefpirome Determination in Pharmaceutical Dosage Forms
Corresponding Author(s) : Basavaraj Hiremath
Asian Journal of Chemistry,
Vol. 33 No. 9 (2021): Vol 33 Issue 9, 2021
Abstract
Quantitative spectrophotometric determination of cefpirome in pure and pharmaceutical dosage has been developed. Method I produces a pink-coloured chromogen peak at λmax 510 nm by reacting diazotized cefpirome drugs with diphenylamine (DPA) in a neutral medium. Method II obtained of a coloured Schiff bases when cefpirome reacts with alcoholic p-dimethylaminobenzaldehyde (PDAB) to produce a yellow-coloured chromogen with a maximum absorption wavelength of 415 nm. In both methods I and II, Beer’s law is followed in the concentration ranges of 0.3-3.0 and 0.5-5.0 μg/mL, respectively, with molar absorptivity of 5.13 × 104 and 2.54 × 104 for each form. At three separate concentrations, intra-day and inter-day (RSD) and relative error (RE) are measured. The current methods are simple, reliable, inexpensive, speedy and highly reproducible and have been tested in broad range of pharmaceutical formulations with statistical comparisons to reference methods.
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- L.G. Martinez, P.C. Falco and A.S. Cabeza, J. Pharm. Biomed. Anal., 29, 405 (2002); https://doi.org/10.1016/S0731-7085(02)00089-4
- H. Tumah, Chemother., 51, 80 (2005); https://doi.org/10.1159/000085614
- B. Lima, S. Bodeau, M.C. Quinton, C. Leven, A.S. Lemaire-Hurtel and Y. Bennis, Antimicrob. Agents Chemother., 63, e00515 (2019); https://doi.org/10.1128/AAC.00515-19
- O’ Neil, The Merck Index, Royal Society of Chemistry: Cambridge, Eds. 15 (2013).
- L.R. Wiseman and H.M. Lamb, Drugs, 54, 117 (1997); https://doi.org/10.2165/00003495-199754010-00013
- H.N. Tumah, Pharmazie, 59, 854 (2004).
- J.F. Roos, J. Lipman and C.M.J. Kirkpatrick, Intensive Care Med., 33, 781 (2007); https://doi.org/10.1007/s00134-007-0573-7
- T.P. Oppe, J. Menegola and E.E.S. Schapoval, Drug Anal. Res., 3, 42 (2019); https://doi.org/10.22456/2527-2616.93809
- D. Breilh, C. Lavallee, A. Fratta, D. Ducint, P. Cony-Makhoul and M.C. Saux, J. Chromatogr. B Biomed. Sci. Appl., 734, 121 (1999); https://doi.org/10.1016/S0378-4347(99)00343-6
- V. Evagelou, A. Tsantili-Kakoulidou and M. Koupparis, J. Pharm. Biomed. Anal., 31, 1119 (2003); https://doi.org/10.1016/S0731-7085(02)00653-2
- P. Zalewski, R. Skibinski, J. Cielecka-Piontek and K. BednarekRajewska, Acta Pol. Pharm., 71, 731 (2014).
- S. Sriwiriyajan and W. Mahatthanatrakul, Arzneimittelforschung, 60, 336 (2010); https://doi.org/10.1055/s-0031-1296297
- M. Nawaz, M.S. Arayne and N. Sultana, Acta Chromatogr., 23, 205 (2011); https://doi.org/10.1556/AChrom.23.2011.2.2
- A. Saeed, N. Sultana and M.A. Nawaz, Pak. J. Pharm. Sci., 19, 38 (2006).
- S. Pavuluri and S. Siddiraju, Int. J. Pharm., 6, 168 (2016).
- J.V.L.N. Seshagiri Rao, D. Anitha Kumari, D. Mallikarjun Rao, P. Nayan Tara and D. Silpa, Indian J. Pharm. Sci., 4, 747 (2005).
- T.P. Oppe, J. Menegola and E.E.S. Schapoval, Drug Anal. Res., 2, 42 (2019); https://doi.org/10.22456/2527-2616.93809
- M.C. Dilip, Asian J. Pharm. Clin. Res., 13, 124 (2020).
- K. Vanitha Prakash and J. Venkateshwar Rao, Asian J. Chem., 20, 2587 (2008).
- International Conference on Hormonization of Technical Requirements for Registration of Pharmaceuticals for Human Use, ICH Harmonized Tripartite Guideline, Validation of Analytical Procedures: Text and Methodology Q2(R 1), London (2005).
References
L.G. Martinez, P.C. Falco and A.S. Cabeza, J. Pharm. Biomed. Anal., 29, 405 (2002); https://doi.org/10.1016/S0731-7085(02)00089-4
H. Tumah, Chemother., 51, 80 (2005); https://doi.org/10.1159/000085614
B. Lima, S. Bodeau, M.C. Quinton, C. Leven, A.S. Lemaire-Hurtel and Y. Bennis, Antimicrob. Agents Chemother., 63, e00515 (2019); https://doi.org/10.1128/AAC.00515-19
O’ Neil, The Merck Index, Royal Society of Chemistry: Cambridge, Eds. 15 (2013).
L.R. Wiseman and H.M. Lamb, Drugs, 54, 117 (1997); https://doi.org/10.2165/00003495-199754010-00013
H.N. Tumah, Pharmazie, 59, 854 (2004).
J.F. Roos, J. Lipman and C.M.J. Kirkpatrick, Intensive Care Med., 33, 781 (2007); https://doi.org/10.1007/s00134-007-0573-7
T.P. Oppe, J. Menegola and E.E.S. Schapoval, Drug Anal. Res., 3, 42 (2019); https://doi.org/10.22456/2527-2616.93809
D. Breilh, C. Lavallee, A. Fratta, D. Ducint, P. Cony-Makhoul and M.C. Saux, J. Chromatogr. B Biomed. Sci. Appl., 734, 121 (1999); https://doi.org/10.1016/S0378-4347(99)00343-6
V. Evagelou, A. Tsantili-Kakoulidou and M. Koupparis, J. Pharm. Biomed. Anal., 31, 1119 (2003); https://doi.org/10.1016/S0731-7085(02)00653-2
P. Zalewski, R. Skibinski, J. Cielecka-Piontek and K. BednarekRajewska, Acta Pol. Pharm., 71, 731 (2014).
S. Sriwiriyajan and W. Mahatthanatrakul, Arzneimittelforschung, 60, 336 (2010); https://doi.org/10.1055/s-0031-1296297
M. Nawaz, M.S. Arayne and N. Sultana, Acta Chromatogr., 23, 205 (2011); https://doi.org/10.1556/AChrom.23.2011.2.2
A. Saeed, N. Sultana and M.A. Nawaz, Pak. J. Pharm. Sci., 19, 38 (2006).
S. Pavuluri and S. Siddiraju, Int. J. Pharm., 6, 168 (2016).
J.V.L.N. Seshagiri Rao, D. Anitha Kumari, D. Mallikarjun Rao, P. Nayan Tara and D. Silpa, Indian J. Pharm. Sci., 4, 747 (2005).
T.P. Oppe, J. Menegola and E.E.S. Schapoval, Drug Anal. Res., 2, 42 (2019); https://doi.org/10.22456/2527-2616.93809
M.C. Dilip, Asian J. Pharm. Clin. Res., 13, 124 (2020).
K. Vanitha Prakash and J. Venkateshwar Rao, Asian J. Chem., 20, 2587 (2008).
International Conference on Hormonization of Technical Requirements for Registration of Pharmaceuticals for Human Use, ICH Harmonized Tripartite Guideline, Validation of Analytical Procedures: Text and Methodology Q2(R 1), London (2005).