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A Comprehensive Review on Promising Phytopharmacological Applications of Chamomile Flower

https://doi.org/10.14233/ajchem.2021.23390
Pallishree Bhukta
Department of Pharmacology, School of Pharmacy and Life Sciences, Centurion University of Technology and Management, P.O. Jatni, Dist. Khurda-752050, India
Deepankar Rath
Department of Pharmacology, School of Pharmacy and Life Sciences, Centurion University of Technology and Management, P.O. Jatni, Dist. Khurda-752050, India
Gurudutta Pattnaik
Department of Pharmacology, School of Pharmacy and Life Sciences, Centurion University of Technology and Management, P.O. Jatni, Dist. Khurda-752050, India
Biswakanth Kar
Department of Pharmacology, School of Pharmaceutical Sciences, Siksha O Anusandhan University, Bhubaneswar-751030, India
Santosh Kumar Ranajit
Department of Pharmacology, School of Pharmacy and Life Sciences, Centurion University of Technology and Management, P.O. Jatni, Dist. Khurda-752050, India

Corresponding Author(s) : Gurudutta Pattnaik

Asian Journal of Chemistry, Vol. 33 No. 11 (2021): Vol 33 Issue 11, 2021

Abstract

Chamomile (Matricaria recutita L., Chamomilla recutita L., Matricaria chamomilla) is one of the most favoured single ingredient herbs. Chamomile tea is prepared by brewing the dried flower heads which has been used as traditional remedy. It is a crop introduced into India, mainly grown in Assam, Uttar Pradesh, Jammu & Kashmir states of India. The valuable unknown properties of this multipurpose herb should be explored to determine the therapeutic properties of its different parts, extracts, oils, etc. The flowers constitute many phenolic compounds like flavonoids, apigenin, patuletin, glucosides, luteolin and quercetin as main components. This herb is used as an antioxidant, antidepressant, antidiarrheal, antimicrobial, anti-inflammatory, antidiabetic, anticarcinogenic and hepatoprotective agents. In addition to that, it is also useful in treatment of gastrointestinal disorders, premenstrual syndrome, knee osteoarthritis andulcerative colitis. Matricaria Recutita chamomilla L. is used for both therapeutically and non-therapeutically around the globe that precipitate its remarkable worth. Chamomile contents of essential oils are widely used in aromatherapy and cosmetics. Most popular chamomile preparation is herbal tea which has been developed and consumed by more than one million cups per day across the globe. This review article briefs about the therapeutic efficiency along with phytology and cultivation techniques.

Keywords

Chamomile Phytochemicals Essential oil Medicinal plant Flavonoids
Bhukta, P., Rath, D., Pattnaik, G., Kar, B., & Kumar Ranajit, S. (2021). A Comprehensive Review on Promising Phytopharmacological Applications of Chamomile Flower. Asian Journal of Chemistry, 33(11), 2864–2870. https://doi.org/10.14233/ajchem.2021.23390
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References
  1. S. Miraj, N. Azizi and S. Kiani, Der Pharm. Lett., 8, 229 (2016).
  2. A. Mekonnen, B. Yitayew, A. Tesema and S. Taddese, Int. J. Microbiol., 2016, 1 (2016); https://doi.org/10.1155/2016/9545693
  3. K.L. Handa, I.C. Chopra and B.K. Abrol, Indian Perfumer, 1, 42 (1957).
  4. European Medicines Agency, Glossary on Herbal Teas (2000). https://www.ema.europa.eu/en/documents/regulatory-proceduralguideline/glossary-herb-al-teas_en.pdf. Accessed 08 July 2020.
  5. M. Marino, C. Bersani and G. Comi, Int. J. Food Microbiol., 67, 187 (2001); https://doi.org/10.1016/S0168-1605(01)00447-0
  6. T. Ogawa, Y. Ishitsuka, Y. Nakamura, N. Okiyama, R. Watanabe, Y. Fujisawa and M. Fujimoto, Clin. Cosmet. Investig. Dermatol., 13, 657 (2020); https://doi.org/10.2147/CCID.S270602
  7. J.K. Srivastava, E. Shankar and S. Gupta, Mol. Med. Report, 1, 895 (2010); https://doi.org/10.3892/mmr.2010.377
  8. J.K. Srivastava and S. Gupta, J. Agric. Food Chem., 55, 9470 (2007); https://doi.org/10.1021/jf071953k
  9. B. Gosztola, S. Sarosi and E. Nemeth, Nat. Prod. Commun., 5, 465 (2010); https://doi.org/10.1177/1934578X1000500325
  10. A. Orav, A. Raal and E. Arak, Nat. Prod. Res., 24, 48 (2010); https://doi.org/10.1080/14786410802560690
  11. C. Avonto, M. Wang, A.G. Chittiboyina, B. Avula, J. Zhao and I.A. Khan, J. Nat. Prod., 76, 1848 (2013); https://doi.org/10.1021/np4003349
  12. T. Kaneko, S. Tahara and F. Takabayashi, Biol. Pharm. Bull., 30, 2052 (2007); https://doi.org/10.1248/bpb.30.2052
  13. Ch. Franz, R. Bauer, R. Carle, D. Tedesco and A. Tubaro, Eds.: K. ZittelEglseer, Study on the Assessments of Plants/Herbs, Plant/Herb Extracts and their Naturally or Synthetically Produced Components as Additives for use in Animal Production, CFT/EFSA/FEEDAP/2005/01, pp. 155-169 (2005).
  14. R. Franke, Eds.: R. Franke and H. Schilcher, Plant Sources, In: Chamomile: Industrial Profiles, CRC Press: Boca Raton, Ed. 1, pp. 39-42 (2005).
  15. A. Leung and S. Foster, Encyclopedia of Common Natural Ingredients used in Food, Drugs and Cosmetics. 2nd ed. John Wiley and Sons: New York, Ed. 2 (1996).
  16. P.N. Misra and L.D. Kapoor, Indian For., 104, 631 (1978).
  17. P.B. Kanjilal and R.S. Singh, J. Agric. Sci., 70, 631 (2000).
  18. D.K. Misra, S.N. Naik, V.K. Srivastava and R. Prasad, J. Med. Arom. Plant Sci., 21, 1020 (1999).
  19. M.A. Der and L. Liberti, Natural Product Medicine: A Scientific Guide to Foods, Drugs, Cosmetics, F. Stickley Co.: George, Philadelphia (1988).
  20. D.L. McKay and J.B. Blumberg, Phytother. Res., 20, 519 (2006); https://doi.org/10.1002/ptr.1900
  21. J.A. Pino, F. Bayat, R. Marbot and J. Aguero, J. Essent. Oil Res., 14, 407 (2002); https://doi.org/10.1080/10412905.2002.9699903
  22. A. Pirzad, H. Alyari, S. Zehtab-Salmasi, A. Mohammadi, M.R. Shakiba, J. Agron., 5, 451 (2006); https://doi.org/10.3923/ja.2006.451.455
  23. C. Mann and E.J. Staba, Eds.: L.E. Craker and J.E. Simon, The Chemistry, Pharmacology and Commercial Formulations of Chamomile. In: Herbs, Spices and Medicinal Plants-Recent Advances in Botany, Horticulture and Pharmacology, Haworth Press Inc.: USA, pp. 235-280 (2002).
  24. R.K. Lal, J.R. Sharma, H.O. Misra and S.P. Singh, Indian J. Agric. Sci., 63, 27 (1993).
  25. N. Misra, R. Luthra, K.L. Singh, S. Kumar and L. Kiran, Eds.: K. Nishi and O. Methcohn, Recent Advances in Biosynthesis of Alkaloids, In: Comprehensive Natural Product Chemistry, Elsevier, pp. 25-69 (1999).
  26. H. Schilcher, P. Imming and S. Goeters, Eds.: R. Franke and H. Schilcher, Active Chemical constituents of Matricaria chamomilla L. syn. Chamomilla recutita (L.) Rauschert; In: Chamomile Industrial Profiles, CRC Press: Boca Raton; pp. 55-76 (2005).
  27. H. Wagner, S. Bladt and E.M. Zgainski, Plant Drug Analysis, SpringerVerlag: Heidelberg, Ed.: 1, pp. 32-34 (1984).
  28. J.C. Jellinek, Perfume Cosmet Aromes, 57, 55 (1984).
  29. A. Tubaro, C. Zilli, C. Redaelli and R. Loggia, Planta Med., 50, 359 (1984); https://doi.org/10.1055/s-2007-969734
  30. A.Y. Leung, Encyclopedia of Common Natural Ingredients used in Food, Drugs and Cosmetics, John Wiley and Sons: New York, Ed.: 1, pp. 110-112 (1980).
  31. V. Jakovlev, O. Isaac, K. Thiemer and R. Kunde, Planta Med., 35, 125 (1979); https://doi.org/10.1055/s-0028-1097194
  32. U. Achterrath-Tuckermann, R. Kunde, E. Flaskamp, O. Isaac and K. Thiemer, Planta Med., 39, 38 (1980); https://doi.org/10.1055/s-2008-1074901
  33. K.H. Baser, B. Demirci, G. Iscan, T. Hashimoto, F. Demirci, Y. Noma and Y. Asakawa, Chem. Pharm. Bull. (Tokyo), 54, 222 (2006); https://doi.org/10.1248/cpb.54.222
  34. N.A. Babenko and E.G. Shakhova, Exp. Gerontol., 41, 32 (2006); https://doi.org/10.1016/j.exger.2005.08.008
  35. R. Avallone, P. Zanoli, G. Puia, M. Kleinschnitz, P. Schreier and M. Baraldi, Biochem. Pharmacol., 59, 1387 (2000); https://doi.org/10.1016/S0006-2952(00)00264-1
  36. V. Svehlikov, R.N. Bennett, F.A. Mellon, P.W. Needs, S. Piacente, P.A. Kroon and Y. Bao, Phytochemistry, 65, 2323 (2004); https://doi.org/10.1016/j.phytochem.2004.07.011
  37. N.P. Povh, C.A. Garcia, M.O.M. Marques and M.A.A. Meireles, Rev. Bras. Plantas Med., 4, 1 (2001).
  38. E. Szoke, E. Maday, G. Marczal and E. Lemberkovics, Acta Hortic., 275 (2003); https://doi.org/10.17660/ActaHortic.2003.597.40
  39. S. Niknam, Z. Tofighi, M.A. Faramarzi, M.A. Abdollahifar, E. Sajadi, R. Dinarvand and T. Toliyat, Daru J. Pharm. Sci., 29, 133 (2021); https://doi.org/10.1007/s40199-021-00392-x
  40. B. Motealleh, P. Zahedi, I. Rezaeian, M. Moghimi, A.H. Abdolghaffari and M.A. Zarandi, J. Biomed. Mater. Res. B Appl. Biomater., 102, 977 (2014); https://doi.org/10.1002/jbm.b.33078
  41. H.J. Glowania, C. Raulin and M. Swoboda, Z. Hautkr., 62, 1267 (1987).
  42. A. Anis, A. Sharshar, S.E. Hanbally and Y. Sadek, J. Equine Vet. Sci., 99, 103406 (2021); https://doi.org/10.1016/j.jevs.2021.103406
  43. M.D. Martins, M.M. Marques, S.K. Bussadori, M.A. Martins, V.C. Pavesi, R.A. Mesquita-Ferrari and K.P. Fernandes, Phytother. Res., 23, 274 (2009); https://doi.org/10.1002/ptr.2612
  44. M. Shokrollahi, S.H. Bahrami, M.H. Nazarpak and A. Solouk, Int. J. Biol. Macromol., 147, 547 (2020); https://doi.org/10.1016/j.ijbiomac.2020.01.067
  45. G. Akduman and I.O. Korkmaz, Herba Polonica, 66, 68 (2020); https://doi.org/10.2478/hepo-2020-0020
  46. L. Weber, K. Kuck, G. Jürgenliemk, J. Heilmann, B. Lipowicz and C. Vissiennon, Biomolecules, 10, 1033 (2020); https://doi.org/10.3390/biom10071033
  47. J.K. Srivastava, M. Pandey and S. Gupta, Life Sci., 85, 663 (2009); https://doi.org/10.1016/j.lfs.2009.09.007
  48. F.G. Miguel, A.H. Cavalheiro, N.F. Spinola, D.L. Ribeiro, G.R.M. Barcelos, L.M.G. Antunes, J.I. Hori, F. Marquele-Oliveira, B.A. Rocha and A.A. Berretta, Evid. Based Complement. Alternat. Med., 2015, 828437 (2015); https://doi.org/10.1155/2015/828437
  49. E.M. Drummond, N. Harbourne, E. Marete, J.C. Jacquier, D. O’Riordan and E.R. Gibney, J. Diet. Suppl., 10, 370 (2013); https://doi.org/10.3109/19390211.2013.830680
  50. F. Sato, Y. Matsukawa, K. Matsumoto, H. Nishino and T. Sakai, Biochem. Biophys. Res. Commun., 204, 578 (1994); https://doi.org/10.1006/bbrc.1994.2498
  51. D.M. Lepley, B. Li, D.F. Birt and J.C. Pelling, Carcinogenesis, 17, 2367 (1996); https://doi.org/10.1093/carcin/17.11.2367
  52. M.L. Kuo and N.C. Yang, Biochem. Biophys. Res. Commun., 212, 767 (1995); https://doi.org/10.1006/bbrc.1995.2035
  53. Y.T. Huang, M.L. Kuo, J.Y. Liu, S.Y. Huang and J.K. Lin, Eur. J. Cancer, 32, 146 (1996); https://doi.org/10.1016/0959-8049(95)00540-4
  54. N. Niisato, Y. Ito and Y. Marunaka, Biochem. Biophys. Res. Commun., 254, 368 (1999); https://doi.org/10.1006/bbrc.1998.9952
  55. A.F. Lenne-Gouverneur, A. Lobstein, G. Haan-Archipoff, G. Duportail, R. Anton and J.G. Kuhry, Mol. Membr. Biol., 16, 157 (1999); https://doi.org/10.1080/096876899294616
  56. C. Chaumontet, C. Droumaguet, V. Bex, C. Heberden, I. Gaillard Sanchez and P. Martel, Cancer Lett., 114, 207 (1997); https://doi.org/10.1016/S0304-3835(97)04664-8
  57. A.T. Smolinski and J.J. Pestka, Food Chem. Toxicol., 41, 1381 (2003); https://doi.org/10.1016/S0278-6915(03)00146-7
  58. T.D. Way, M.C. Kao and J.K. Lin, J. Biol. Chem., 279, 4479 (2004); https://doi.org/10.1074/jbc.M305529200
  59. C. Danciu, O. Cioanca, C. Watz Farcas, M. Hancianu, R. Racoviceanu, D. Muntean, I. Zupko, C. Oprean, C. Tatu, V. Paunescu, M. Proks, Z. Diaconeasa, C. Soica, I. Pinzaru and C. Dehelean, Anticancer. Agents Med. Chem., 21, 187 (2020); https://doi.org/10.2174/1871520620666200807213734
  60. M.A. Gates, S.S. Tworoger, J.L. Hecht, I. De Vivo, B. Rosner and S.E. Hankinson, Int. J. Cancer, 121, 2225 (2007); https://doi.org/10.1002/ijc.22790
  61. S. Shukla, A. Mishra, P. Fu, G.T. MacLennan, M.I. Resnick and S. Gupta, FASEB J., 19, 2042 (2005); https://doi.org/10.1096/fj.05-3740fje
  62. S. Evans, N. Dizeyi, P.A. Abrahamsson and J. Persson, Anticancer Res., 10, 3917 (2009).
  63. M.L. Kuo, J.K. Lin, T.S. Huang and N.C. Yang, Cancer Lett., 87, 91 (1994); https://doi.org/10.1016/0304-3835(94)90414-6
  64. S.C. Lee, C.Y. Kuan, C.C. Yang and S.D. Yang, Anticancer Res., 18, 1117 (1998).
  65. S. Gupta, F. Afaq and H. Mukhtar, Oncogene, 21, 3727 (2002); https://doi.org/10.1038/sj.onc.1205474
  66. A. Kato, Y. Minoshima, J. Yamamoto, I. Adachi, A.A. Watson and R.J. Nash, J. Agric. Food Chem., 56, 8206 (2008); https://doi.org/10.1021/jf8014365
  67. M. Eddouks, A. Lemhadri, N.A. Zeggwagh and J.-B. Michel, Diabetes Res. Clin. Pract., 67, 189 (2005); https://doi.org/10.1016/j.diabres.2004.07.015
  68. M. Cemek, S. Kaga, N. Simsek, M.E. Büyükokuroglu and M. Konuk, J. Nat. Med., 62, 284 (2008); https://doi.org/10.1007/s11418-008-0228-1
  69. S.S. Khan, R. Najam, H. Anser, B. Riaz and N. Alam, Pak. J. Pharm. Sci., 27, 1509 (2014).
  70. U. Albrecht, V. Muller, B. Schneider and R. Stange, BMJ Open Gastroenterol., 1, e000015 (2014); https://doi.org/10.1136/bmjgast-2014-000015
  71. U. Kroll and C. Cordes, Phytomedicine, 13, 12 (2006); https://doi.org/10.1016/j.phymed.2006.03.016
  72. M.T. Khayyal, M. Seif-El-Nasr, M.A. El-Ghazaly, S.N. Okpanyi, O. Kelber and D. Weiser, Phytomedicine, 13, 56 (2006); https://doi.org/10.1016/j.phymed.2006.03.019
  73. H. Viola, C. Wasowski, M. Levi de Stein, C. Wolfman, R. Silveira, F. Dajas, J. Medina and A. Paladini, Planta Med., 61, 213 (1995); https://doi.org/10.1055/s-2006-958058
  74. Y. Jia, J. Zou, Y. Wang, X. Zhang, Y. Shi, Y. Liang, D. Guo and M. Yang, J. Food Biochem., 45, e13547 (2021); https://doi.org/10.1111/jfbc.13547
  75. H. Ebrahimi, A. Mardani, M.H. Basirinezhad, A. Hamidzadeh and F. Eskandari, Explore, (2021); https://doi.org/10.1016/j.explore.2020.12.012
  76. H. Ashraf, A. Salehi, M. Sousani and M.H. Sharifi, Evid. Based Complement. Alternat. Med., 2021, 1 (2021); https://doi.org/10.1155/2021/6626394
  77. P.F.P. Chaves, P.A.S. Hocayen, J.L. Dallazen, M.F. de Paula Werner, M. Iacomini, R. Andreatini and L.M.C. Cordeiro, Int. J. Biol. Macromol., 164, 1675 (2020); https://doi.org/10.1016/j.ijbiomac.2020.08.039
  78. D. Lelli, L. Cortese and C. Pedone, Adv. Exp. Med. Biol., 1308, 217 (2021); https://doi.org/10.1007/978-3-030-64872-5_15
  79. C. Caleja, A. Ribeiro, L. Barros, J.C.M. Barreira, A.L. Antonio, M. Beatriz P.P. Oliveira, M.F. Barreiro and I.C.F.R. Ferreira, Food Chem., 199, 720 (2016); https://doi.org/10.1016/j.foodchem.2015.12.085
  80. M.A. Jabri, K. Rtibi and H. Sebai, Nutr. Neurosci., (2020); https://doi.org/10.1080/1028415X.2020.1859727
  81. S. Parham, A.Z. Kharazi, H.R. Bakhsheshi-Rad, H. Nur, A.F. Ismail, S. Sharif, S. RamaKrishna and F. Berto, Antioxidants, 9, 1309 (2020); https://doi.org/10.3390/antiox9121309
  82. W. Wang, R.F. Yue, Z. Jin, L.M. He, R. Shen, D. Du and Y.Z. Tang, J. Pharm. Pharmacol., 72, 1645 (2020); https://doi.org/10.1111/jphp.13347
  83. P. Aertgeerts, M. Albring, F. Klaschka, T. Nasemann, R. Patzelt-Wenczler, K. Rauhut and B. Weigl, Z. Hautkr., 60, 270 (1985).
  84. H.P. Nissen, H. Blitz and H.W. Kreyel, Z. Hautkr., 63, 84 (1988).
  85. E. Kassi, Z. Papoutsi, N. Fokialakis, I. Messari, S. Mitakou and P. Moutsatsou, J. Agric. Food Chem., 52, 6956 (2004); https://doi.org/10.1021/jf0400765
  86. R. Shoara, M.H. Hashempur, A. Ashraf, A. Salehi, S. Dehshahri and Z. Habibagahi, Complement. Ther. Clin. Pract., 21, 181 (2015); https://doi.org/10.1016/j.ctcp.2015.06.003
  87. M.G.L. Hertog, E.J.M. Feskens, D. Kromhout, M.G.L. Hertog, P.C.H. Hollman, M.G.L. Hertog and M.B. Katan, Lancet, 342, 1007 (1993); https://doi.org/10.1016/0140-6736(93)92876-U
  88. P.S. Lorenzo, M.C. Rubio, J.H. Medina and E. Adler-Graschinsky, Eur. J. Pharmacol., 312, 203 (1996); https://doi.org/10.1016/0014-2999(96)00486-4
  89. S. Charuluxananan, P. Sumethawattana, R. Kosawiboonpol, W. Somboonviboon and T. Werawataganon, J. Med. Assoc. Thai., 87, 185 (2004).
  90. S. Pierre, L. Crosbie and A.K. Duttaroy, Platelets, 16, 469 (2005); https://doi.org/10.1080/09537100500129540
  91. H. Sebai, M.A. Jabri, A. Souli, K. Hosni, K. Rtibi, O. Tebourbi, J. ElBenna and M. Sakly, Gen. Physiol. Biophys., 34, 263 (2015); https://doi.org/10.4149/gpb_2014039
  92. J.W. Budzinski, B.C. Foster, S. Vandenhoek and J.T. Arnason, Phytomedicine, 7, 273 (2000); https://doi.org/10.1016/S0944-7113(00)80044-6
  93. A.M. Heck, B.A. DeWitt and A.L. Lukes, Am. J. Health Syst. Pharm., 57, 1221 (2000); https://doi.org/10.1093/ajhp/57.13.1221
  94. W. Abebe, J. Clin. Pharm. Ther., 27, 391 (2002); https://doi.org/10.1046/j.1365-2710.2002.00444.x
  95. M.M. Larzelere and P. Wiseman, Prim. Care, 29, 339 (2002); https://doi.org/10.1016/S0095-4543(01)00003-3
  96. J. Subiza, J.L. Subiza, M. Alonso, M. Hinojosa, R. Garcia, M. Jerez and E. Subiza, Ann. Allergy, 65, 127 (1990).
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