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Vol. 33 No. 11 (2021): Vol 33 Issue 11, 2021

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Fabrication of Substituted-Hydroxyapatite/Poly(vinyl pyrrolidone)-Poly(methyl methacrylate) Biocomposites for Bone Tissue Engineering Applications

https://doi.org/10.14233/ajchem.2021.23385
G. Priya
Department of Chemistry, Government Arts College for Women, Salem-636008, India ; Department of Chemistry, Shri Sakthikailassh Women’s College, Salem-636003, India
N. Vijayakumari
Department of Chemistry, Government Arts College for Women, Salem-636008, India

Corresponding Author(s) : G. Priya

priya88chemistry@gmail.com

Asian Journal of Chemistry, Vol. 33 No. 11 (2021): Vol 33 Issue 11, 2021

Abstract

Present work based on the development and incorporation of zinc-cerium substituted hydroxyapatite (ZCHA) nanoparticles into the host material of the dual polymer blend of poly(vinyl pyrrolidone) (PVD)-poly(methyl methacrylate) (PMMA). Numerous characterization techniques such as FTIR, XRD and SEM-EDX have been used in morphological and structural investigations of prepared nanoparticles and ZCHA reinforced PMMA-PVD biocomposites. The mechanical properties of ZCHA/PVD-PMMA biocomposites, like compressive strength was evaluated. To examine the biocompatibility of biocomposites, hemocompatibility experiments have been carried out. The antimicrobial activities of biocomposites toward Gram-positive and Gram-negative bacteria have also been tested and the cytotoxic existence of biocomposites has been evaluated using the MTT assay experiment. The developed ZCHA/PVD-PMMA biocomposites is suggested to provide the finest medicinal benefits in the application of biomaterials.

Keywords

Bone Biocomposite Hydroxyapatite Poly(vinyl pyrrolidone) Poly(methyl methacrylate) Cerium Zinc
Priya, G., & Vijayakumari, N. (2021). Fabrication of Substituted-Hydroxyapatite/Poly(vinyl pyrrolidone)-Poly(methyl methacrylate) Biocomposites for Bone Tissue Engineering Applications. Asian Journal of Chemistry, 33(11), 2774–2780. https://doi.org/10.14233/ajchem.2021.23385
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