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Vol. 33 No. 11 (2021): Vol 33 Issue 11, 2021

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Eco-Friendly Novel Synthesis, Characterization of 2,3-Disubstituted 4-Thiazolidinone Derivatives and their Antimicrobial Evaluations

https://doi.org/10.14233/ajchem.2021.23399
Ashutosh Pathak
Department of Pharmaceutical Sciences, Shalom Institute of Health and Allied Sciences, Sam Higginbottom University of Agriculture, Technology & Sciences (SHUATS), Naini, Prayagraj-211007, India ; Department of Pharmacy, Maharishi University of Information Technology, Sitapur Road, IIM Bypass, Lucknow-226013, India
P. Malairajan
Department of Pharmaceutical Sciences, Shalom Institute of Health and Allied Sciences, Sam Higginbottom University of Agriculture, Technology & Sciences (SHUATS), Naini, Prayagraj-211007, India
Parmesh Kumar Dwivedi
Department of Pharmaceutical Chemistry, Amity Institute of Pharmacy, Lucknow, Amity University Uttar Pradesh, Sector 125, Noida-201313, India
Devdutt Chaturvedi
Department of Chemistry, School of Physical Sciences, Mahatma Gandhi Central University, Motihari-845401, India

Corresponding Author(s) : Parmesh Kumar Dwivedi

parmeshdwivedi@gmail.com

Asian Journal of Chemistry, Vol. 33 No. 11 (2021): Vol 33 Issue 11, 2021

Abstract

A total of nine derivatives of 4-thiazolidinone were synthesized involving the reaction of benzene-1,2-diamine with 4-aminobenzoic acid followed by reaction with substituted benzaldehyde to get the Schiff bases. These synthesized Schiff bases were further reacted with thioglycolic acid to get the desired thiazolidinones (29-37). In addition to conventional synthesis, the microwave irradiation method has also been employedfor the synthesis of these compounds which provides not only pollution free and eco-friendly environment but also excellent yields. The results showed that 2-substituted thiazolidinone derivatives exhibit good antibacterial activity. It was also recorded that the compounds containing -Cl, -NO2 group with thiazolidinone nucleus are more active than other compounds of the synthesized series.

Keywords

4-Thiazolidinones Schiff bases Biological activity Benzimidazoles Microwave synthesis
Pathak, A., Malairajan, P., Kumar Dwivedi, P., & Chaturvedi, D. (2021). Eco-Friendly Novel Synthesis, Characterization of 2,3-Disubstituted 4-Thiazolidinone Derivatives and their Antimicrobial Evaluations. Asian Journal of Chemistry, 33(11), 2685–2692. https://doi.org/10.14233/ajchem.2021.23399
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