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Vol. 33 No. 11 (2021): Vol 33 Issue 11, 2021

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Review on Synthesis Route of Quinazoline Based Hybrid Derivatives

https://doi.org/10.14233/ajchem.2021.23373
Pravin Deharkar
Department of Chemistry, Dr. Ambedkar College, Deekshabhoomi, Nagpur-440010, India
Shridhar Satpute
Department of Chemistry, Dr. Ambedkar College, Deekshabhoomi, Nagpur-440010, India
Deepa Panhekar
Department of Chemistry, Dr. Ambedkar College, Deekshabhoomi, Nagpur-440010, India

Corresponding Author(s) : Pravin Deharkar

pdeharkar@gmail.com

Asian Journal of Chemistry, Vol. 33 No. 11 (2021): Vol 33 Issue 11, 2021

Abstract

Quinazolines are amidst the most significant pharmacological compounds in natural and medicinal chemistry, with a wide variety of pharmacological things, including antifungal, antibacterial, anti-inflammatory, anti-HIV, anticancer and analgesic activity. Designing innovative quinazolines, studying possible techniques to synthesize quinazolines, examining diverse features of quinazolines and looking for prospective uses of quinazolines have all become more important in the last two decades due to their multiple possible applications. The current review paper discusses the synthesis of quinazolines using the multi-component synthetic technique that is environmentally friendly, mild and atom-efficient. The discussion is separated into sections based on the key processes used to construct quinazoline scaffolds to provide an efficient approach for a more significant grasp. The most recent references have also been taken into account. The review should prove useful in future research on quinazoline synthesis and developing a more promising synthetic technique.

Keywords

Bicyclic compounds Pyrimidine Amidines Nitriles Synthesis Green chemistry Quinazolines Quinazolinones
Deharkar, P., Satpute, S., & Panhekar, D. (2021). Review on Synthesis Route of Quinazoline Based Hybrid Derivatives. Asian Journal of Chemistry, 33(11), 2525–2547. https://doi.org/10.14233/ajchem.2021.23373
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