Synthesis and Anticoccidial Activities of Novel N-(2-Aminophenyl)-2-quinazolinone-acetamide Hydrochloride

Chun-Rong Yan; Li Yang; A-Rong Guo; Kui Nie; Yu-Liang Wang

doi:10.14233/ajchem.2013.14162

Issue

Vol. 25 No. 9 (2013): Vol 25 Issue 9

Issue Published : March 25, 2013

This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis and Anticoccidial Activities of Novel N-(2-Aminophenyl)-2-quinazolinone-acetamide Hydrochloride

https://doi.org/10.14233/ajchem.2013.14162

Chun-Rong Yan

College of Chemistry, Sichuan University, Chengdu 610064, Sichuan Province, P.R. China ; College of Chemistry and Chemical Engineering, Yibin University, Yinbin 644000, P.R. China

Li Yang

College of Chemistry and Chemical Engineering, Yibin University, Yinbin 644000, P.R. China

A-Rong Guo

College of Chemistry, Sichuan University, Chengdu 610064, Sichuan Province, P.R. China

Kui Nie

College of Animal Science and Technology, Southwest University, Chongqing 6400715, P.R. China

Yu-Liang Wang

College of Chemistry, Sichuan University, Chengdu 610064, Sichuan Province, P.R. China

Corresponding Author(s) : Yu-Liang Wang

chemwang2008@163.com; allendk@163.com

Asian Journal of Chemistry, Vol. 25 No. 9 (2013): Vol 25 Issue 9
Article Published : April 9, 2013

Abstract

Eight novel N-(2-aminophenyl)-2-quinazolinone-acetamide hydrochloride were synthesized and their structures were identified by ¹H NMR, MS and IR spectra. Seven of the new compounds were chosen for anticoccidial activity test and the results showed that N-(2-aminophenyl)-2-(6-methyl-8-bromo quinazolinone)acetamide hydrochloride (3h) exhibited anticoccidial activity against Eimeria tenella in the chicken' diet with a dose of 18 mg/Kg.

Keywords

N-(2-Aminophenyl)-2-quinazolinone-acetamide hydrochloride Anticoccidial activity Eimeria tenella

Yan, C.-R., Yang, L., Guo, A.-R., Nie, K., & Wang, Y.-L. (2013). Synthesis and Anticoccidial Activities of Novel N-(2-Aminophenyl)-2-quinazolinone-acetamide Hydrochloride. Asian Journal of Chemistry, 25(9), 4970–4974. https://doi.org/10.14233/ajchem.2013.14162

Download Citation

References

C.F. Duffy, G.F. Mathis and R.F. Power, Vet. Parasitol., 130, 185 (2005).
C.H. Yun, H.S. Lillehoj and E.P. Lillehoj, Dev. Comp. Immunol., 24, 303 (2000).
V. Cozma and A. Titilincu, CAB Rev., 2, 61 (2007).
G. Greif and B. Stephan, Parasitol. Res., 82, 706 (1996).
H.D. Chapman, Avian Pathol., 26, 221(1997).
C.R. Yan, J. Xu, Y.B. Weng, J. Li, Y.L. Wang and H. Chen, Chem. Biol. Drug Des., 72, 314 (2008).
Y.Y. Wang, C.R. Yan, Y.B. W, H. Jin and H. Chen, Pestic. Biochem. Phys., 93, 85 (2009).
Y. Zou, C.R. Yan, Y.B. W, J. Li, K.Q. Wu, Y.L. Wang and Y.Z. Wang, J. Chem. Res., 4, 252 (2009).
C.R. Yan, X.Y. Zeng, Y.P. Yao, K. Nie, Y.L. Wang and H. Chen, J. Chem. Res., 2, 71 (2010).
Z. Wang, L.J. Zhou, Y.L. Wang, Y.B. Weng, J. He and K. Nie, J. Chem. Res., 7, 378 (2011).
J.H. You, C.W. Ye, Y.B. Weng, X.H. Mo and Y.L. Wang, ARKIVOC, 1 (2008).
C.W. Ye, J.H. You, X.F. Li, R. You, Y.B. Weng, J. Li and Y.L. Wang, Pestic. Biochem. Phys., 97, 194 (2010).
Y.Y. Zhan, G.M. Chen, Y.B. Weng, R.L. Li, Y.L. Wang and Y.Z. Wang, Lett. Drug. Des. Discov., 7, 471 (2010).
R. Bernard and N.Y. Baker, US Patent 2775597 (1956).
W.P. Emanuel, US Patent 3320124 (1967).
H. Xie, D. Ng, S.N. Savinov, B. Dey, P.D. Kwong, R. Wyatt, A.B. Smith III and W.A. Hendrickson, J. Med. Chem., 50, 4898 (2007).
G.A. Roth and J.J. Tai, J. Heterocycl. Chem., 33, 2051 (1996).
L. Baerfacker, R. Kast, N. Griebenow, H. Meier, P. Kolkhof, B. AlbrechtKuepper, A. Nitsche, J.P. Stasch, D. Schneider and N. Teusch, WO Patent 2010020366 (2010).
L. Oerfi, F. Waczek, J. Pato, I. Varga, B. Hegymegi-Barakonyi, R.A. Houghten and G. Keri, Curr. Med. Chem., 11, 2549 (2004).
S. Inoue, Y. Tsuboi, Y. Ikeda, T. Nakajima, N. Fujimoto, S. Iwasaki and Y. Fukano, WO Patent 2011148922 (2011).
W.D. Schmitz, J.J. Bronson, A.P. Degnan and I.E. Whitney, US Patent 2009/0018,163 (2008).
T. Tomio, T. Yoshikazu, H. Masa, N. Hiroshi and S. Kiyoshi, US Patent 5215981 (1990).
G.Q. Li, S. Kanu, F.Y. Xiang, S.M. Xiao, L. Zhang, H.W. Chen and H.J. Ye, Vet. Parasitol., 119, 261 (2004).
S.D. Folz, B.L. Lee, L.H. Nowakowsk, D.L. Rector and B.M. Folz, J. Parasitol., 75, 696 (1989).

References

C.F. Duffy, G.F. Mathis and R.F. Power, Vet. Parasitol., 130, 185 (2005).

C.H. Yun, H.S. Lillehoj and E.P. Lillehoj, Dev. Comp. Immunol., 24, 303 (2000).

V. Cozma and A. Titilincu, CAB Rev., 2, 61 (2007).

G. Greif and B. Stephan, Parasitol. Res., 82, 706 (1996).

H.D. Chapman, Avian Pathol., 26, 221(1997).

C.R. Yan, J. Xu, Y.B. Weng, J. Li, Y.L. Wang and H. Chen, Chem. Biol. Drug Des., 72, 314 (2008).

Y.Y. Wang, C.R. Yan, Y.B. W, H. Jin and H. Chen, Pestic. Biochem. Phys., 93, 85 (2009).

Y. Zou, C.R. Yan, Y.B. W, J. Li, K.Q. Wu, Y.L. Wang and Y.Z. Wang, J. Chem. Res., 4, 252 (2009).

C.R. Yan, X.Y. Zeng, Y.P. Yao, K. Nie, Y.L. Wang and H. Chen, J. Chem. Res., 2, 71 (2010).

Z. Wang, L.J. Zhou, Y.L. Wang, Y.B. Weng, J. He and K. Nie, J. Chem. Res., 7, 378 (2011).

J.H. You, C.W. Ye, Y.B. Weng, X.H. Mo and Y.L. Wang, ARKIVOC, 1 (2008).

C.W. Ye, J.H. You, X.F. Li, R. You, Y.B. Weng, J. Li and Y.L. Wang, Pestic. Biochem. Phys., 97, 194 (2010).

Y.Y. Zhan, G.M. Chen, Y.B. Weng, R.L. Li, Y.L. Wang and Y.Z. Wang, Lett. Drug. Des. Discov., 7, 471 (2010).

R. Bernard and N.Y. Baker, US Patent 2775597 (1956).

W.P. Emanuel, US Patent 3320124 (1967).

H. Xie, D. Ng, S.N. Savinov, B. Dey, P.D. Kwong, R. Wyatt, A.B. Smith III and W.A. Hendrickson, J. Med. Chem., 50, 4898 (2007).

G.A. Roth and J.J. Tai, J. Heterocycl. Chem., 33, 2051 (1996).

L. Baerfacker, R. Kast, N. Griebenow, H. Meier, P. Kolkhof, B. AlbrechtKuepper, A. Nitsche, J.P. Stasch, D. Schneider and N. Teusch, WO Patent 2010020366 (2010).

L. Oerfi, F. Waczek, J. Pato, I. Varga, B. Hegymegi-Barakonyi, R.A. Houghten and G. Keri, Curr. Med. Chem., 11, 2549 (2004).

S. Inoue, Y. Tsuboi, Y. Ikeda, T. Nakajima, N. Fujimoto, S. Iwasaki and Y. Fukano, WO Patent 2011148922 (2011).

W.D. Schmitz, J.J. Bronson, A.P. Degnan and I.E. Whitney, US Patent 2009/0018,163 (2008).

T. Tomio, T. Yoshikazu, H. Masa, N. Hiroshi and S. Kiyoshi, US Patent 5215981 (1990).

G.Q. Li, S. Kanu, F.Y. Xiang, S.M. Xiao, L. Zhang, H.W. Chen and H.J. Ye, Vet. Parasitol., 119, 261 (2004).

S.D. Folz, B.L. Lee, L.H. Nowakowsk, D.L. Rector and B.M. Folz, J. Parasitol., 75, 696 (1989).

Issue

Vol. 25 No. 9 (2013): Vol 25 Issue 9

Synthesis and Anticoccidial Activities of Novel N-(2-Aminophenyl)-2-quinazolinone-acetamide Hydrochloride

Corresponding Author(s) : Yu-Liang Wang

Abstract

Keywords

Full Article

Download Citation

References

Table Of Contents