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Synthesis of Novel Magnetic Water-Soluble Chitosan as Potential Magnetic Resonance Imaging Contrast Agents
Corresponding Author(s) : Xiaoyan Zhang
Asian Journal of Chemistry,
Vol. 25 No. 9 (2013): Vol 25 Issue 9
Abstract
A magnetic water-soluble chitosan as potential contrast agents for MRI was synthesized by a simple new route. The morphology and structure of the magnetic water-soluble chitosan were characterized by FTIR, FESEM and XRD. The magnetic properties were characterized by in vitro and T2-weighted FLASH image experiments. In vitro magnetic resonance imaging demonstrates that the magnetic water-soluble chitosan could greatly enhance the contrast for image under magnetic field and the contrast was enhanced with the concentration. The results of T2-relaxivities indicates that the magnetic water-soluble chitosan provided high relaxivity. The paper presents a new, simple and economic route to preparing magnetic water-soluble chitosan using for potential magnetic resonance imaging contrast agents.
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- P. C. Lauterbur, Nature, 242, 190 (1973).
- P. Lebdusková, J. Kotek, P. Hermann, L.V. Elst, R.N. Muller, I. Lukes and J.A. Peters, Bioconjug. Chem., 15, 881 (2004).
- M. Bartolini, Magn. Resonan. Imag., 21, 541 (2003).
- H. Kobayashi, S. Kawamoto, T. Saga, N. Sato, T. Ishimori, J. Konishi, K. Ono, K. Togashi and M.W. Brechbiel, Bioconjug. Chem., 12, 587 (2001).
- J. Feng, J. Inorg. Biochem., 92, 193 (2002).
- J. Feng, G. Sun, F. Pei and M. Liu, Bioorg. Med. Chem., 11, 3359 (2003).
- Z. Li, W. Li, X. Li, F. Pei, X. Wang and H. Lei, J. Inorg. Biochem., 101, 1036 (2007).
- Z. Zhang, R. He, K. Yan, Q.-N. Guo, Y.-G. Lu, X.-X. Wang, H. Lei and Z.-Y. Li, Bioorg. Med. Chem. Lett., 19, 6675 (2009).
- J. Lu, S. Ma, J. Sun, C. Xia, C. Liu, Z. Wang, X. Zhao, F. Gao, Q. Gong, B. Song, X. Shuai, H. Ai and Z. Gu, Biomaterials, 30, 2919 (2009).
- M. Baghi, M.G. Mack, M. Hambek, J. Rieger, T. Vogl, W. Gstoettner and R. Knecht, Anticancer Res., 25, 3665 (2005).
- M. Abo, Z. Chen, L.-J. Lai, T. Reese and B. Bjelke, Neuro Report, 12, 1543 (2001).
- H. Lee, E. Lee, D.K. Kim, N.K. Jang, Y.Y. Jeong and S. Jon, J. Am. Chem. Soc., 128, 7383 (2006).
- D.K. Kim, M. Mikhaylova, F.H. Wang, J. Kehr, B. Bjelke, Y. Zhang, T. Tsakalakos and M. Muhammed, Chem. Mater., 15, 4343 (2003).
- H. Lee, E. Heekim, H. Shao and B. Kookkwak, J. Magn. Magnet. Mater., 293, 102 (2005).
- E.H. Kim, Y. Ahn and H.S. Lee, J. Alloys Compd., 434, 633 (2007).
- Z.T. Tsai, J.F. Wang, H.Y. Kuo, C.R. Shen, J.J. Wang and T.C. Yen, J. Magn. Magnet. Mater., 322, 208 (2010).
- E.H. Kim, H.S. Lee and H. Sha, On the Convergence of Bio-Information-, Environmental-, Energy-, Space- and Nano-Technologies, Parts 1 and 2, pp. 277-279,1044 (2005).
- K. Matsumoto, H. Yakumaru, M. Narazaki, H. Nakagawa, K. Anzai, H. Ikehira and N. Ikota, Magn. Resonan. Imag., 26, 117 (2008).
References
P. C. Lauterbur, Nature, 242, 190 (1973).
P. Lebdusková, J. Kotek, P. Hermann, L.V. Elst, R.N. Muller, I. Lukes and J.A. Peters, Bioconjug. Chem., 15, 881 (2004).
M. Bartolini, Magn. Resonan. Imag., 21, 541 (2003).
H. Kobayashi, S. Kawamoto, T. Saga, N. Sato, T. Ishimori, J. Konishi, K. Ono, K. Togashi and M.W. Brechbiel, Bioconjug. Chem., 12, 587 (2001).
J. Feng, J. Inorg. Biochem., 92, 193 (2002).
J. Feng, G. Sun, F. Pei and M. Liu, Bioorg. Med. Chem., 11, 3359 (2003).
Z. Li, W. Li, X. Li, F. Pei, X. Wang and H. Lei, J. Inorg. Biochem., 101, 1036 (2007).
Z. Zhang, R. He, K. Yan, Q.-N. Guo, Y.-G. Lu, X.-X. Wang, H. Lei and Z.-Y. Li, Bioorg. Med. Chem. Lett., 19, 6675 (2009).
J. Lu, S. Ma, J. Sun, C. Xia, C. Liu, Z. Wang, X. Zhao, F. Gao, Q. Gong, B. Song, X. Shuai, H. Ai and Z. Gu, Biomaterials, 30, 2919 (2009).
M. Baghi, M.G. Mack, M. Hambek, J. Rieger, T. Vogl, W. Gstoettner and R. Knecht, Anticancer Res., 25, 3665 (2005).
M. Abo, Z. Chen, L.-J. Lai, T. Reese and B. Bjelke, Neuro Report, 12, 1543 (2001).
H. Lee, E. Lee, D.K. Kim, N.K. Jang, Y.Y. Jeong and S. Jon, J. Am. Chem. Soc., 128, 7383 (2006).
D.K. Kim, M. Mikhaylova, F.H. Wang, J. Kehr, B. Bjelke, Y. Zhang, T. Tsakalakos and M. Muhammed, Chem. Mater., 15, 4343 (2003).
H. Lee, E. Heekim, H. Shao and B. Kookkwak, J. Magn. Magnet. Mater., 293, 102 (2005).
E.H. Kim, Y. Ahn and H.S. Lee, J. Alloys Compd., 434, 633 (2007).
Z.T. Tsai, J.F. Wang, H.Y. Kuo, C.R. Shen, J.J. Wang and T.C. Yen, J. Magn. Magnet. Mater., 322, 208 (2010).
E.H. Kim, H.S. Lee and H. Sha, On the Convergence of Bio-Information-, Environmental-, Energy-, Space- and Nano-Technologies, Parts 1 and 2, pp. 277-279,1044 (2005).
K. Matsumoto, H. Yakumaru, M. Narazaki, H. Nakagawa, K. Anzai, H. Ikehira and N. Ikota, Magn. Resonan. Imag., 26, 117 (2008).