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Vol. 25 No. 9 (2013): Vol 25 Issue 9

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Sesquiterpene Glucosides from Nicotiana tabacum and Their Biological Activity

https://doi.org/10.14233/ajchem.2013.14147
Guangyu-Yu Yang
Key Laboratory of Tobacco Chemistry of Yunnan Province, Yunnan Academy of Tobacco Science, Kunming 650106, P.R. China
Wei Zhao
Key Laboratory of Tobacco Chemistry of Yunnan Province, Yunnan Academy of Tobacco Science, Kunming 650106, P.R. China
Yong-Kuan Chen
Key Laboratory of Tobacco Chemistry of Yunnan Province, Yunnan Academy of Tobacco Science, Kunming 650106, P.R. China
Zhang-Yu Chen
Key Laboratory of Tobacco Chemistry of Yunnan Province, Yunnan Academy of Tobacco Science, Kunming 650106, P.R. China
Qiufen Hu
Key Laboratory of Ethnic Medicine Resource Chemistry (Yunnan University of Nationalities), State Ethnic Affairs Commission & Ministry of Education, Kunming 650031, P.R. China
Ming-Ming Miao
Key Laboratory of Tobacco Chemistry of Yunnan Province, Yunnan Academy of Tobacco Science, Kunming 650106, P.R. China

Corresponding Author(s) : Ming-Ming Miao

mmmiao@cyats.com

Asian Journal of Chemistry, Vol. 25 No. 9 (2013): Vol 25 Issue 9

Abstract

A new sesquiterpene glucoside (1), together with two known sesquiterpene glucosides (2-3) were isolated from the leaves of Nicotiana tabacum. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1-3 were tested for their anti HIV-1 activities and cytotoxicity. The results showed that compounds 1-3 have weak cytotoxic abilities and anti HIV-1 bioctivities, respectively.

Keywords

Nicotiana tabacum Sesquiterpene glucosides Anti HIV-1 activitiy Cytotoxicity
Yang, G.-Y., Zhao, W., Chen, Y.-K., Chen, Z.-Y., Hu, Q., & Miao, M.-M. (2013). Sesquiterpene Glucosides from Nicotiana tabacum and Their Biological Activity. Asian Journal of Chemistry, 25(9), 4932–4934. https://doi.org/10.14233/ajchem.2013.14147
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