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Synthesis and Antimicrobial Activities on Staphylicoccus aureus of Miscellaneous Atomic Curcumin Derivatives
Corresponding Author(s) : Qiyong Huai
Asian Journal of Chemistry,
Vol. 25 No. 9 (2013): Vol 25 Issue 9
Abstract
Miscellaneous atomic curcumin derivatives were synthesized with biotin, lipolic acid, isonicotinic acid and curcumin, employing the acylchloride method. Their chemical structures were confirmed by IR, MS and 1H NMR spectroscopy. The antimicrobial activities of these new compounds and curcumin were explored with Staphylicoccus aureus under the same conditions. The result showed that the antimicrobial activity of these new compounds were better than curcumin especially the MIC of lipolic curcumin was 2.5 mg/mL, which was 4 times better than curcumin.
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References
A. Foryst-Ludwig, M. Neumann, W. Schneider-Brachert and M. Naumann, Biochem. Biophys. Res. Commun., 16, 1065 (2004)
Y. Aratanechemugei, I.T. Komira, H. Moteki, H. Katsuzaki, K. Imai and H. Hibasami, Int. J. Mol. Med., 9, 481 (2002).
S. Mishra, K. Karmodiya, N. Surolia and A. Surolia, Bioorg. Med. Chem., 16, 2894 (2008).
X. Li and J. Chu, Chin. J. Antibiot., 33, 6 (2009).
G.P. Biewenga, G.R. Haenen and A. Bast, Gen. Pharmacol. J., 29, 315 (1997).
R.A. Hammoud, C.S. Vaccari, S.H. Nagamia and B.V. Khan, Vasc. Health Risk Manag., 3, 937 (2007).
Yan Cenhu, Biofunctionalization of Polylactide-Polyethylene Glycol (PLA-PEG) Nanoparticles for Targeting to Brain Glioma, Master's Dissertations of Tianjin University, pp. 25-34 (2007).
K.-J. Kim, H.-H. Yu, J.-D. Cha, S.-J. Seo, N.-Y. Choi and Y.-O. You, Phytother. Res., 19, 599 (2005).