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Vol. 25 No. 8 (2013): Vol 25 Issue 8

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Clean Synthesis of Pharmaceutical Intermediate 2,2'-Dithiobis(benzothiazole) in Fluidized Bed Reactor

https://doi.org/10.14233/ajchem.2013.14030
Chunguang Chen
School of Chemical Engineering And Technology, Tianjin University, Tianjin, P.R. China ; Huangdao Import and Export Inspection and Quarantine Bureau, Qingdao, P.R. China
Weiwei Niu
School of Polymer Science and Engineering, Qingdao University of Science & Technology, Qingdao, P.R. China
Yaqing Feng
School of Chemical Engineering And Technology, Tianjin University, Tianjin, P.R. China
Xuexi Chen
School of Chemical Engineering And Technology, Qingdao University of Science and Technology, Qingdao, P.R. China

Corresponding Author(s) : Chunguang Chen

chen_chun_guang@hotmail.com

Asian Journal of Chemistry, Vol. 25 No. 8 (2013): Vol 25 Issue 8

Abstract

Refined 2-mercaptobenzothiazole was produced by recrystallization from 2-mercaptobenzothiazole with industrial grade and oxidized to 2,2'-dithiobis(benzothiazole), using oxygen as an oxidant, nitric oxide as a oxygen carrier and alcohols as solvents, in a circulating fluidized reactor under one-step oxidation. 2,2'-Dithiobis(benzothiazole) was thus obtained with high purity up to 99 %, melting point at 183 ºC, high yield over 98 %, through the optimization of reaction parameters as reaction time, temperature, reactants ratio, with less waste generation and emission during the production process. Alcohol solvents can be reused after purification.

Keywords

Pharmaceutical intermediate 2,2'-Dithiobis(benzothiazole) Circulating fluidized bed reactor
Chen, C., Niu, W., Feng, Y., & Chen, X. (2013). Clean Synthesis of Pharmaceutical Intermediate 2,2’-Dithiobis(benzothiazole) in Fluidized Bed Reactor. Asian Journal of Chemistry, 25(8), 4493–4497. https://doi.org/10.14233/ajchem.2013.14030
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