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Vol. 25 No. 8 (2013): Vol 25 Issue 8

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Reaction Between Trimethyl phosphite, Dimethyl Acetylenedicarboxylate and 1,3-Dicarbonyl Compounds: An Efficient Method for the Synthesis of Dimethoxyphosphoryl Succinic Acid Dimethoxy Ester Derivatives

https://doi.org/10.14233/ajchem.2013.13429
Maryam Yazdanian
Department of Medicinal Chemistry, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran
Ali Asadipour
Department of Medicinal Chemistry, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran

Corresponding Author(s) : Ali Asadipour

aliasadipour@yahoo.com; aliasadipour@kmu.ac.ir

Asian Journal of Chemistry, Vol. 25 No. 8 (2013): Vol 25 Issue 8

Abstract

The addition of a phosphorus nucleophile to an acceptor such as alkyne, certainly represents one of the most versatile and powerful tools for the formation of P-C bonds. This offers the possibility to access many diversely functionalized products. In this article, the reaction between trimethyl phosphite and dimethyl acetylenedicarboxylate (DMAD) with 1,3-dicarbonyl compounds such as dimedone, acetyl acetone and diethyl malonate proceeds smoothly to produce stable dimethoxyphosphoryl succinic acid dimethyl ester derivatives (4), (11) and (12) in excellent yields.

Keywords

Phosphite Acetylenedicarboxylate Dimedone Phosphoryl succinic acid dimethyl ester
Yazdanian, M., & Asadipour, A. (2013). Reaction Between Trimethyl phosphite, Dimethyl Acetylenedicarboxylate and 1,3-Dicarbonyl Compounds: An Efficient Method for the Synthesis of Dimethoxyphosphoryl Succinic Acid Dimethoxy Ester Derivatives. Asian Journal of Chemistry, 25(8), 4162–4164. https://doi.org/10.14233/ajchem.2013.13429
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