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Synthesis and In Vitro Cytotoxic Evaluation of 7-Chloro-4-anilino-quinoline Amide Derivatives
Corresponding Author(s) : Tran Khac Vu
Asian Journal of Chemistry,
Vol. 25 No. 8 (2013): Vol 25 Issue 8
Abstract
A series of new amide derivatives of 4-anilino-quinoline have been synthesized and evaluated in vitro cytotoxic activity against the human hepatocellular carcinoma (HepG2), human lung carcinoma (SK-LU-1) and human breast cancer (MCF-7). Compound 5g was found to be most potent cytotoxic activity against HepG2 and MCF-7 cell lines with IC50 values of 2.09 and 4.63 μg/mL, respectively. Compound 5e exhibited significant cytotoxic activity against three cell lines with IC50 values ranging from 5-10 μg/mL.
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- For statistical information about cancer, see: WorldHealth Organisation: http://www.who.int/mediacentre/factsheets/fs297/en/.
- J.D. Jordan, E. M. Landau and R. Iyengar, Cell, 103, 193 (2000).
- P. Blume-Jensen and T. Hunter, Nature, 411, 355 (2001).
- T. Eicher and S. Hauptmann, The Chemistry of Heterocycles, WileyVCH, Weinheim, edn. 2, p. 316 (2003).
- P.G. Bray, S.A. Ward and P.M. O'Neill, Curr. Top. Microbiol. Immunol., 295, 3 (2005).
- (a) P. Narender, U. Srinnivas, M. Ravinder, A.B. Rao, C. Ramesh, K. Harakishore, B. Gangadasu, U.S.N. Murthy and J.V. Rao, Bioorg. Med. Chem., 14, 4600 (2006); (b) A. Nayyar, A. Malde, E. Couthinho and R. Jain, Bioorg. Med. Chem., 14, 7302 (2006).
- G. Roma, M.D. Braccio, G. Grossi, F. Mattioli and M. Ghia, Eur. J. Med. Chem., 35, 1021 (2000).
- R. Kakadiya, H. Dong, A. Kumar, D. Narsinh, X. Zhang, T.C. TingChao Chou, T.C. Lee, A. Anamik Shah and T.L. Su, Bioorg. Med. Chem., 18, 2285 (2010).
- A. Dlugosz and D. Dus, Farmaco, 51, 367 (1996).
- S. Kumar, S. Bawa, S. Drabu, H. Gupta, L. Machwal and R. Kumar, Eur. J. Med. Chem., 46, 670 (2011).
- (a) R.C. Montenegro, L.V. Lotufo, M.O. Moraes, C. do O Pessoa, F.A.R. Rodrigues, M.L.F. Bispo, L.N.F. Cardoso, C.R. Kaiser and M.V.N. Souza, Med. Chem., 7, 599 (2011); (b) J. Bernzweig, B. Heiniger, K. Prasain, J. Lu, D.H. Hua and T.A. Nguyen, Med. Chem., 7, 448 (2011).
- (a) J.A. Adams, Chem. Rev., 101, 2271 (2001); (b) J. Dumas, Curr. Opin. Drug Discov. Develop., 4, 378 (2001).
- E.I. Aly, J. Am. Sci., 6, 73 (2010).
- P.M.S. Chauhan, S. Sharma and D.S. Bhakuni, Indian J. Chem., 25B, 828 (1986).
- D.A. Scudiero, R.H. Shoemaker, D.P. Kenneth, A. Monks, S. Tierney, T.H. Nofziger, M.J. Currens, D. Seniff and M.R. Boyd, Cancer Res., 48, 4827 (1988).
References
For statistical information about cancer, see: WorldHealth Organisation: http://www.who.int/mediacentre/factsheets/fs297/en/.
J.D. Jordan, E. M. Landau and R. Iyengar, Cell, 103, 193 (2000).
P. Blume-Jensen and T. Hunter, Nature, 411, 355 (2001).
T. Eicher and S. Hauptmann, The Chemistry of Heterocycles, WileyVCH, Weinheim, edn. 2, p. 316 (2003).
P.G. Bray, S.A. Ward and P.M. O'Neill, Curr. Top. Microbiol. Immunol., 295, 3 (2005).
(a) P. Narender, U. Srinnivas, M. Ravinder, A.B. Rao, C. Ramesh, K. Harakishore, B. Gangadasu, U.S.N. Murthy and J.V. Rao, Bioorg. Med. Chem., 14, 4600 (2006); (b) A. Nayyar, A. Malde, E. Couthinho and R. Jain, Bioorg. Med. Chem., 14, 7302 (2006).
G. Roma, M.D. Braccio, G. Grossi, F. Mattioli and M. Ghia, Eur. J. Med. Chem., 35, 1021 (2000).
R. Kakadiya, H. Dong, A. Kumar, D. Narsinh, X. Zhang, T.C. TingChao Chou, T.C. Lee, A. Anamik Shah and T.L. Su, Bioorg. Med. Chem., 18, 2285 (2010).
A. Dlugosz and D. Dus, Farmaco, 51, 367 (1996).
S. Kumar, S. Bawa, S. Drabu, H. Gupta, L. Machwal and R. Kumar, Eur. J. Med. Chem., 46, 670 (2011).
(a) R.C. Montenegro, L.V. Lotufo, M.O. Moraes, C. do O Pessoa, F.A.R. Rodrigues, M.L.F. Bispo, L.N.F. Cardoso, C.R. Kaiser and M.V.N. Souza, Med. Chem., 7, 599 (2011); (b) J. Bernzweig, B. Heiniger, K. Prasain, J. Lu, D.H. Hua and T.A. Nguyen, Med. Chem., 7, 448 (2011).
(a) J.A. Adams, Chem. Rev., 101, 2271 (2001); (b) J. Dumas, Curr. Opin. Drug Discov. Develop., 4, 378 (2001).
E.I. Aly, J. Am. Sci., 6, 73 (2010).
P.M.S. Chauhan, S. Sharma and D.S. Bhakuni, Indian J. Chem., 25B, 828 (1986).
D.A. Scudiero, R.H. Shoemaker, D.P. Kenneth, A. Monks, S. Tierney, T.H. Nofziger, M.J. Currens, D. Seniff and M.R. Boyd, Cancer Res., 48, 4827 (1988).