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Vol. 25 No. 8 (2013): Vol 25 Issue 8

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Ion-Pair Extraction Spectrophotometric Determination of Trace Amounts of Imipramine

https://doi.org/10.14233/ajchem.2013.13952
M. Sheibani
Department of Chemistry, Faculty of Science, Omidiyeh Branch, Islamic Azad University, Omidiyeh, Iran
Z.G. Afshar
Department of Chemistry, Faculty of Science, Omidiyeh Branch, Islamic Azad University, Omidiyeh, Iran

Corresponding Author(s) : M. Sheibani

marjan.sheibani@gmail.com

Asian Journal of Chemistry, Vol. 25 No. 8 (2013): Vol 25 Issue 8

Abstract

A simple, sensitive and selective extraction-spectrophotometric method for the determination of trace amounts of imipramine is reported. The imipramine-orange II ion-pair in acidic media is quantitatively extracted into chloroform and its absorbance is measured at 487 nm at room temperature. The effect of different variables such as solvent, volume of extracting solvent, volume of anionic reagent, pH, ionic strength (NaCl 0.1 M) and shaking time is investigated and optimum conditions for quantitative extraction of imipramine is obtained. Linear calibration graph over the imipramine concentration range of 0.03-7.00 μg mL–1 and regression coefficient of 0.9999 is obtained. The relative standard deviation of 10 replicate determination of 2 μg mL–1 of imipramine is 1.945 %. Limit of detection of the method is 0.022 μg mL–1. The method is used for determination of imipramine in 10 mg, 25 mg, 50 mg tablets.

Keywords

Imipramine Extraction Orange II Determination
Sheibani, M., & Afshar, Z. (2013). Ion-Pair Extraction Spectrophotometric Determination of Trace Amounts of Imipramine. Asian Journal of Chemistry, 25(8), 4305–4307. https://doi.org/10.14233/ajchem.2013.13952
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