Anti-oxidative and Anti-inflammatory Effects of Flavonoids from the Silk of Zea mays Linn

M.H. Oh; K.I. Choe; S.H. Cho; M.S. Jeong; S.C. Myung; S.J. Seo; S.E. Choi; M.W. Lee

doi:10.14233/ajchem.2013.13943

Issue

Vol. 25 No. 8 (2013): Vol 25 Issue 8

Issue Published : March 7, 2013

This work is licensed under a Creative Commons Attribution 4.0 International License.

Anti-oxidative and Anti-inflammatory Effects of Flavonoids from the Silk of Zea mays Linn

https://doi.org/10.14233/ajchem.2013.13943

M.H. Oh

College of Pharmacy, Chung Ang University, Seoul 156-756, South Korea

K.I. Choe

College of Pharmacy, Chung Ang University, Seoul 156-756, South Korea

S.H. Cho

College of Pharmacy, Chung Ang University, Seoul 156-756, South Korea

M.S. Jeong

College of Pharmacy, Chung Ang University, Seoul 156-756, South Korea

S.C. Myung

College of Medicine, Chung Ang University, Seoul 156-756, South Korea

S.J. Seo

College of Medicine, Chung Ang University, Seoul 156-756, South Korea

S.E. Choi

Department of Cosmetology Science, Nambu University, Gwangju City 506-706, South Korea

M.W. Lee

College of Pharmacy, Chung Ang University, Seoul 156-756, South Korea

Corresponding Author(s) : M.W. Lee

mwlee@cau.ac.kr

Asian Journal of Chemistry, Vol. 25 No. 8 (2013): Vol 25 Issue 8
Article Published : March 18, 2013

Abstract

Activity-guided isolation of the silk of Zea mays Linn (ZMS) yielded three flavonoids, chrysoeriol-6-C-b-boivinopyranosyl-7-O-b-glucopyranoside (1), chrysoeriol (2) and luteolin (3). Anti-oxidative activity was measured using the 2,2-diphenyl-1-picryl-hydrazyl and superoxide dismutase-like superoxide anion (generated by xanthine oxidase/hypoxanthine) scavenging assays. Anti-inflammatory activity was confined by quantifying the protein and mRNA levels of inducible nitric oxide synthase and cyclooxygenase-2 in lipopolysaccharide-stimulated HaCaT cells using western blotting and real-time polymerase chain reaction. The results showed that luteolin 3 exhibited potent 2,2-diphenyl-1-picryl-hydrazyl (IC₅₀ = 18.31 ± 1.29 μM) and superoxide dismutase-like superoxide anion scavenging activity (IC₅₀ = 1.47 ± 0.14 μM) and dose-dependently inhibited the protein expression of inducible nitric oxide synthase and cyclooxygenase-2 as well as their mRNA levels.

Keywords

Zea mays Linn Flavonoid Anti-oxidative Anti-inflammatory Inducible nitric oxide synthase Cyclooxygenase-2

Oh, M., Choe, K., Cho, S., Jeong, M., Myung, S., Seo, S., … Lee, M. (2013). Anti-oxidative and Anti-inflammatory Effects of Flavonoids from the Silk of Zea mays Linn. Asian Journal of Chemistry, 25(8), 4293–4297. https://doi.org/10.14233/ajchem.2013.13943

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References

E.M. Choi and J.K. Hwang, Fitoterapia, 75, 557 (2004).

H.Y. Joo and K.T. Lim, Environ. Toxicol. Pharmacol., 27, 247 (2009).

Y.N. Li, Y.L. Wu, Z.H. Jia and J.S. Qi, J. Ethnopharmacol., 119, 305 (2008).

J.L. Wallace, Mem. Inst. Oswaldo Cruz., 100, 5 (2005).

J.R. Vane, J.A. Mitchell, I. Appleton, A.T. Linson, D. Bishop-Bailey, J. Croxtall and D.A. Willoughby, Proc. Nat. Acad. Sci. USA, 91, 2046 (1994).

T. Csont, S. Viappiani, J. Sawicka, S. Slee, J.Y. Altarejos, I. BatinicHaberle and R. Schulz, J. Mol. Cell Cardiol., 39, 833 (2005).

T.A. Swierkosz, J.A. Mitchell, T.D. Warner, R.M. Botting and J.R. Vane, Br. J. Pharmacol., 114, 1335 (1995).

H.W. Lim, S.J. Kang, M. Park, J.H. Yoon, B.H. Han, S.E. Choi and M.W. Lee, Nat. Prod. Sci., 12, 221 (2006).

M.A. Ebrahimzadeh, F. Pourmorad and S. Hafezi, Turk. J. Biol., 32, 43 (2008).

R. Suzuki, Y. Okada and T. Okuyama, J. Nat. Prod., 66, 564 (2003).

S.C. Ren, Z.L. Liu and X.L. Ding, J. Med. Plant Res., 3, 1009 (2009).

Z. Maksimovíc, D. Malencíc and N. Kovacevíc, Bioresour. Technol., 96, 873 (2005).

A. El-Ghorab, K.F. El-Massry and T. Shibamoto, J. Agric. Food Chem., 55, 9124 (2007).

Z.A. Maksimovic and N. Kovacevic, Fitoterapia, 74, 144 (2003).

K.A. Kim, H.H. Shin, S.K. Choi and H.S. Choi, Biosci. Biotech. Biochem., 69, 1848 (2005).

T. Hatano, R. Edamatsu, M. Hiramatsu, A. Mori, Y. Fujita, T. Yasuhara, T. Yoshida and T. Okuda, Chem. Pharm. Bull., 37, 3005 (1989).

I. Parejo, F. Viladomat, J. Bastida, A. Rosas-Romero, N. Flerlage, J. Burillo and C. Codina, J. Agric. Food Chem., 50, 6882 (2002).

R. Suzuki, Y. Okada and T. Okuyama, Chem. Pharm. Bull., 51, 1186 (2003).

A.S. Awaad, D.J. Maitland and G.A. Soliman, Med. Chem. Lett., 16, 4624 (2006).

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S. Hougee, A. Sanders, J. Faber, Y.M.F. Graus, W.B. van Den Berg, J. Garssen, H.F. Smit and M.A. Hoijer, Biochem. Pharmacol., 69, 241 (2005)

Issue

Vol. 25 No. 8 (2013): Vol 25 Issue 8

Anti-oxidative and Anti-inflammatory Effects of Flavonoids from the Silk of Zea mays Linn

Corresponding Author(s) : M.W. Lee

Abstract

Keywords

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