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Interaction of Cr(VI) Binding with Bovine Serum Albumin: Reaction Mechanisms and Thermodynamic Properties
Corresponding Author(s) : Xiaoyun Ran
Asian Journal of Chemistry,
Vol. 25 No. 8 (2013): Vol 25 Issue 8
Abstract
The interaction between Cr(VI) and bovine serum albumin (BSA) was investigated by spectroscopic method combined with thermodynamic experiment. Binding model of Cr(VI)-BSA system was found. The binding parameters were determined and the mechanism of interaction was interpreted. The effect of Cr(VI) acting on the bovine serum albumin's conformation was detected and the microenvironment change of tyrosine and tryptophan residues induced by Cr(VI) was explored. The enthalpy change DH and the entropy change DS of Cr(VI)-BSA system were calculated, which suggested that the main binding feature between Cr(VI) and bovine serum albumin is hydrophobic force.
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- P. Suksabye, A. Nakajima, P. Thiravetyan, Y. Baba and W. Nakbanpote, J. Hazard. Mater., 161, 1103 (2009).
- H.K. Mandal, A. Kundu, S. Balti and A. Mahapatra, J. Colloid Interf. Sci., 378, 110 (2012).
- H. Yasui, Y. Kunori and H. Sakurai, Chem. Lett., 32, 1032 (2003).
- J.R. Lakowicz, Principles of Fluorescence Spectroscopy Springer, New York (2006).
- P.G. Wu and L. Brand, Anal. Biochem., 218, 1 (1994).
- M. Guo, W.J. Lü. M.H. Li and W. Wang, Eur. J. Med. Chem., 43, 2140 (2008).
- Y. Liu, M.X.X and J. Kang, Acta Chim. Sinica, 61, 1305 (2003).
- M.J. Peng, S.Y. Shi and Y.P. Zhang, Environ. Toxicol. Pharmacol., 33, 327 (2012).
- P.D. Ross and S. Subramanian, Biochemistry, 20, 3096 (1981)
References
P. Suksabye, A. Nakajima, P. Thiravetyan, Y. Baba and W. Nakbanpote, J. Hazard. Mater., 161, 1103 (2009).
H.K. Mandal, A. Kundu, S. Balti and A. Mahapatra, J. Colloid Interf. Sci., 378, 110 (2012).
H. Yasui, Y. Kunori and H. Sakurai, Chem. Lett., 32, 1032 (2003).
J.R. Lakowicz, Principles of Fluorescence Spectroscopy Springer, New York (2006).
P.G. Wu and L. Brand, Anal. Biochem., 218, 1 (1994).
M. Guo, W.J. Lü. M.H. Li and W. Wang, Eur. J. Med. Chem., 43, 2140 (2008).
Y. Liu, M.X.X and J. Kang, Acta Chim. Sinica, 61, 1305 (2003).
M.J. Peng, S.Y. Shi and Y.P. Zhang, Environ. Toxicol. Pharmacol., 33, 327 (2012).
P.D. Ross and S. Subramanian, Biochemistry, 20, 3096 (1981)