Copyright (c) 2013 AJC
This work is licensed under a Creative Commons Attribution 4.0 International License.
A Potential Method for Recycling of Gastrodin Separated from Urine
Corresponding Author(s) : Honggui Zhang
Asian Journal of Chemistry,
Vol. 25 No. 8 (2013): Vol 25 Issue 8
Abstract
Gastrodia rhizome is a famous Chinese medicinal plant and has been widely used in China for centuries. In this paper, we have, preparatively seperated gastrodin from the rats' urine after metabolism. Male Wistar rats were orally given crude gastrodin water solution and their urine was collected for continuously 6 h. The collected urine was absorbed with Macroporous resin D101 and desorbed with ethanol water solution (5:95, v/v) to give crude gastrodin. The crude gastrodin was then purified by silica gel column chromatography to get 262 mg gastrodin over 98 % in purity. The total recovery yield of gastrodin was ca. 70.4 %. Though low recovery, our results provided a potential way to recycle gastrodin because of huge amounts need of Gastrodia rhizome in China every year.
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- C.J. Bulpitt, Yan Li, P.F. Bulpitt and J. Wang, J. Royal Soc. Med., 100, 558 (2007).
- H.B. Li and F. Chen, J. Chromatogr. A, 1052, 229 (2004).
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- X. Zeng, S. Zhang, L. Zhang, K. Zhang and X. Zheng, Planta Med., 72, 1359 (2006).
- X. Wang and S. Zeng, Acta Pharm. Sin., 45, 1497 (2010).
- E.S. Ong, M.Y. Heng, S.N. Tan, J.W. Hong Yong, H. Koh, C.C. Teo and C.S. Hew, J. Sep. Sci., 30, 2130 (2007).
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References
C.J. Bulpitt, Yan Li, P.F. Bulpitt and J. Wang, J. Royal Soc. Med., 100, 558 (2007).
H.B. Li and F. Chen, J. Chromatogr. A, 1052, 229 (2004).
X. Xu, Y. Lu and X. Bie, Planta Med., 73, 650 (2007).
J.-N. Dai, Y. Zong, L.-M. Zhong, Y.-M. Li, W. Zhang, L.-G. Bian, Q.-L. Ai, Y.-D. Liu, J. Sun and D. Lu, PLoS One, 6, e21891 (2011).
X. Zeng, S. Zhang, L. Zhang, K. Zhang and X. Zheng, Planta Med., 72, 1359 (2006).
X. Wang and S. Zeng, Acta Pharm. Sin., 45, 1497 (2010).
E.S. Ong, M.Y. Heng, S.N. Tan, J.W. Hong Yong, H. Koh, C.C. Teo and C.S. Hew, J. Sep. Sci., 30, 2130 (2007).
Y. Yang, F.M. Han, P. Du and Y. Chen, Acta Pharm. Sin., 45, 484 (2010).
Y.J. Fu, Y.G. Zu, W. Liu, C.L. Hou, L.Y. Chen, S.M. Li, X.G. Shi and M.H. Tong, J. Chromatogr. A, 1139, 206 (2007).
X. Li, J. Sipple, Q. Pang and W. Du, Blood, 119, 4162 (2012).
Z.Q. Qu, Y. Zhou, Y.S. Zeng, Y.K. Lin, Y. Li, Z.Q. Zhong and W.Y. Chan, PLoS One, 7, e29641 (2012).
L. Lu, J. Yuan and S. Zhang, Rejuvenating Activity of Salidroside (SDS): Dietary Intake of SDS Enhances the Immune Response of Aged rats, Age (Dordr) (2012).
H. Ito, M. Miyake, E. Nishitani, K. Mori, T. Hatano, T. Okuda, T. Konoshima, M. Takasaki, M. Kozuka, T. Mukainaka, H. Tokuda, H. Nishino and T. Yoshida, Cancer Lett., 143, 5 (1999).