Antimicrobial and Antitumor Activities of Crude Extracts and Isolated Compounds from Euphorbia humifusa

Jianbo Lin; Haiqing Zhao; Ba Hang; Haji Akber Aisa

doi:10.14233/ajchem.2013.13854

Issue

Vol. 25 No. 7 (2013): Vol 25 Issue 7

Issue Published : January 18, 2013

This work is licensed under a Creative Commons Attribution 4.0 International License.

Antimicrobial and Antitumor Activities of Crude Extracts and Isolated Compounds from Euphorbia humifusa

https://doi.org/10.14233/ajchem.2013.13854

Jianbo Lin

Key Laboratory of Chemistry of Plant Resources in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, P.R. China

Haiqing Zhao

Key Laboratory of Chemistry of Plant Resources in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, P.R. China

Ba Hang

Key Laboratory of Chemistry of Plant Resources in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, P.R. China

Haji Akber Aisa

Key Laboratory of Chemistry of Plant Resources in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, P.R. China

Corresponding Author(s) : Haji Akber Aisa

haji@ms.xjb.ac.cn

Asian Journal of Chemistry, Vol. 25 No. 7 (2013): Vol 25 Issue 7
Article Published : February 5, 2013

Abstract

Euphorbia humifusa Willd. has been used in traditional Chinese medicine. Herein we report the isolation of its constituents and the testing results of their antimicrobial and antitumor activities. The results show that the crude petroleum ether, chloroform, ethyl acetate, butanol and residual methanol fractions exert such activities. Particularly, the crude petroleum ether and ethyl acetate fractions exhibit antigrowth activity against Staphyloccocus aureus with MIC 0.5 mg/mL. Petroleum ether and chloroform fractions significantly exhibit potent antigrowth activity against Caco-2 cells, with IC₅₀ value of 0.059 and 0.025 mg/mL, respectively. The promising bioactivities of the crude petroleum ether fractions guided the first isolation of compounds: 24-methylene cycloartanone (2), dibutyl phthalate (3), hexacosanol (4) and bis-(2-ethylhexyl) phthalate (5) from this species. The antimicrobial activities of compounds 1-2 were evaluated. The tested compounds exhibit potent antigrowth activity against Staphyloccocus aureus, Escherichia coli and Canidia albicans.

Keywords

Euphorbia humifusa Ethyl acetate extract Antimicrobial activity Antitumor activity

Lin, J., Zhao, H., Hang, B., & Akber Aisa, H. (2013). Antimicrobial and Antitumor Activities of Crude Extracts and Isolated Compounds from Euphorbia humifusa. Asian Journal of Chemistry, 25(7), 3957–3960. https://doi.org/10.14233/ajchem.2013.13854

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References

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References

F. Sahin, M Güllüce, D. Daferera,A. Sökmen, M. Sökmen, M. Polissiou and G. Agar, H Özer, Food Cont., 15, 549 (2004).

C. Thetsrimuang, S. Khammuang, K. Chiablaem, C. Srisomsap and R. Sarnthima, Food Chem., 128, 634 (2011).

A.G. Ramchandani, R.S. Chettiyar and S.S. Pakhale, Food Chem., 119, 298 (2010).

P.-H. Chuang, C.-W. Lee, J.-Y. Chou, M. Murugan, B.-J. Shieh and H.-M. Chen, Bioresour. Technol., 98, 232 (2007).

Y. Peng, L. Zhang, F.o Zeng and J.F. Kennedy, Carbohyd. Polym., 59, 385 (2005).

G. Webester, Ann. Missouri Bot. Gard., p. 33-144 (1994).

P.K. Singla and K. Pathak, Fitoterapia, 61, 483 (1990).

C. Valente, M. Pedro, A. Duarte, M.S.J. Nascimento, P.M. Abreu and M.-J.U. Ferreira, J. Nat. Prod., 67, 902 (2004).

S. Sutthivaiyakit, M. Thapsut and V. Prachayasittikul, Phytochemistry, 53, 947 (2000).

J. Hohmann, D. Rédei, P. Forgo, J. Molnár, G. Dombi and T. Zorig, J. Nat. Prod., 66, 976 (2003).

D. Natarajan, S.J. Britto, K. Srinivasan, N. Nagamurugan, C. Mohanasundari and G. Perumal, J. Ethnopharmacol., 102, 123 (2005).

M. Sudhakar, Ch.V. Rao, P.M. Rao, D.B. Raju and Y. Venkateswarlu, Fitoterapia, 77, 378 (2006).

Pharmacopoeia Commission of the Ministry of Public Health of PRC: Pharmacopoeia of the People's Republic of China (Part 1), Medical Science Press, Beijing, p. 118 (2010).

T. Yoshida, Y. Amakura, Y.Z. Liu and T. Okuda, Chem. Pharm. Bull. (Tokyo), 42, 1803 (1994).

Z.-Q. Lu, G.-T. Chen, J.-Q. Zhang, H.-L. Huang, S.-H. Guan and D.-A. Guo, Helv. Chim. Acta, 90, 2245 (2007).

D. Kalemba and A. Kunicka, Curr. Med. Chem., 10, 813 (2003).

L. Runhui, W. Hanbo and K. Lingyi, Chinese Trad. Herbal Drugs, 32, 107 (2001).

Y.P. Shi and Z.J. Jia, Indian J. Chem., 36B, 1038 (1997).

G.M. Cabrera and A.M. Seldes, J. Nat. Prod., 58, 1920 (1995).

V.L.T. Hoang, Y. Li and S.-K. Kim, Bioorg. Amp.; Med. Chem. Lett., 18, 2083 (2008).

A.N. Starratt, Phytochemistry, 11, 293 (1972).

W. De-Eknamkul and B. Potduang, Phytochemistry, 62, 389 (2003).

F.F. Knapp and H.J. Nicholas, Steroids, 16, 329 (1970).

T.L.G. Lemos, P.C.L. Nogueira, J.W. Alencar and A.A. Craveiro, J. Essent. Oil Res., 7, 561 (1995).

A. Lao, F. Yasuo and T. Takashi, Chem. Pharm. Bull., 32, 723 (1984).

M.G.D. Carvalho, M.A.R. Cardozo, F.E.A. Catunda and A.G. de Carvalho, Ann. Brazilian Acad. Sci., 82, 561 (2010).

Issue

Vol. 25 No. 7 (2013): Vol 25 Issue 7

Antimicrobial and Antitumor Activities of Crude Extracts and Isolated Compounds from Euphorbia humifusa

Corresponding Author(s) : Haji Akber Aisa

Abstract

Keywords

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