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Vol. 25 No. 7 (2013): Vol 25 Issue 7

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Synthesis and Studies on Anticonvulsant Activity of 8-Alkoxy-[1,2,4]triazolo[4,3-a]pyrazine

https://doi.org/10.14233/ajchem.2013.13703
Li-Ping Guan
School of Food, Drug & Medicine, Zhejiang Ocean University, Zhoushan 316004, P.R. China
Rui-Peng Zhang
College of Pharmacy, Yanbian University, Yanji 133000, Jili Province, P.R. China
Yue Chang
School of Food, Drug & Medicine, Zhejiang Ocean University, Zhoushan 316004, P.R. China ; College of Pharmacy, Yanbian University, Yanji 133000, Jili Province, P.R. China
Xi-Xi Gan
School of Food, Drug & Medicine, Zhejiang Ocean University, Zhoushan 316004, P.R. China

Corresponding Author(s) : Li-Ping Guan

glp730@yahoo.com.cn

Asian Journal of Chemistry, Vol. 25 No. 7 (2013): Vol 25 Issue 7

Abstract

In this study, a series of new 8-alkoxy-[1,2,4]triazolo[4,3-a]pyrazine derivatives were synthesized and their anticonvulsant activity and neurotoxicity were evaluated by the maximal electroshock test and the rotarod test, respectively. The most promising compounds 3d (8-butoxy-[1,2,4]triazolo[4,3-a]pyrazine) and 3f (8-hexyloxy-[1,2,4]triazolo[4,3-a]pyrazine) showed a median effective dose of 44 and 35.3 mg/kg and had protective index value of 3.2 and 4.8, respectively. To explain the possible mechanism of anticonvulsant activity, all compounds were tested in chemical induced model in anti pentylenetetrazol test.

Keywords

Anticonvulsant activity Maximal electroshock test [1,2,4]Triazolo[4,3-a]pyrazine Pentylenetetrazol
Guan, L.-P., Zhang, R.-P., Chang, Y., & Gan, X.-X. (2013). Synthesis and Studies on Anticonvulsant Activity of 8-Alkoxy-[1,2,4]triazolo[4,3-a]pyrazine. Asian Journal of Chemistry, 25(7), 3660–3664. https://doi.org/10.14233/ajchem.2013.13703
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