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Synthesis and Cytotoxicity of Coumarin Derivatives and Nordentatin
Corresponding Author(s) : Chavi Yenjai
Asian Journal of Chemistry,
Vol. 25 No. 7 (2013): Vol 25 Issue 7
Abstract
Nordentatin and 10 coumarin derivatives were synthesized and evaluated for cytotoxicity. Compounds 6, 7, 9 and 13 showed cytotoxicity against the NCI-H187 cell line with IC50 value ranging of 3-7 μg/mL. Among synthesized coumarins, compounds 4 and 13 demonstrated cytotoxicity against the KB cell line with IC50 values of 3.94 and 6.44 μg/mL, respectively. Fortunately, coumarins 4 and 7 may be one of the new lead compounds for the development of anticancer agents due to reason that they showed weak and inactive against normal cells.
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- C. Yenjai and S. Wanich, Bioorg. Med. Chem. Lett., 20, 2821 (2010).
- U. Songsiang, S. Pitchuanchom, C. Boonyarat, C. Hahnvajanawong and C. Yenjai, Eur. J. Med. Chem., 45, 3794 (2010).
- T. Thongthoom, P. Promsuwan and C. Yenjai, Eur. J. Med. Chem., 46, 3755 (2011).
- C. Yenjai, S. Sripontan, P. Sriprajun, P. Kittakoop, A. Jintasirikul, M. Tanticharoen and Y. Thebtaranonth, Planta Med., 66, 277 (2000).
- U. Songsiang, T. Thongthoom, C. Boonyarat and C. Yenjai, J. Nat. Prod., 74, 208 (2011).
- T. Thongthoom, U. Songsiang, C. Phaosiri and C. Yenjai, Arch. Pharm. Res., 33, 675 (2010).
- K. Noipha, T. Thongthoom, U. Songsiang, C. Boonyarat and C. Yenjai, Diabetes Res. Clin. Pract., 90, e67 (2010).
- T. Nakamura, N. Kodama, Y. Arai, T. Kumamoto, Y. Higuchi, C. Chaichantipyuth, T. Ishikawa, K. Ueno and S. Yano, J. Nat. Med., 63, 21 (2009).
- Z. Luo, L. Boonyaratanakornkit, C.T. Che, C.A.J. Erdelmeier, H.H.S. Fong and N.R. Farnsworth, J. Nat. Prod., 6, 1161 (1986).
- Y.Y. Chan, C.H. Li, Y.C. Shen and T.S. Wu, Chem. Pharm. Bull., 58, 61 (2010).
- A. Murakami, G. Gao, M. Omura, M. Yano, C. Ito, H. Furukawa, D. Takahashi, K. Koshimizu and H. Ohigashi, Bioorg. Med. Chem. Lett., 10, 59 (2000).
- E. Melliou, P. Magiatis, S. Mitaku,A. Skaltsounis, E. Chinou and I. Chinou, J. Nat. Prod., 68, 78 (2005).
- J.O. Brien, I. Wilson, T. Orton and F. Pognan, Eur. J. Biochem., 267, 5421 (2000).
- L. Hunt, M. Jordan, M. De Jesus and F.M. Wurm, Biotechnol. Bioeng., 65, 201 (1999)
References
C. Yenjai and S. Wanich, Bioorg. Med. Chem. Lett., 20, 2821 (2010).
U. Songsiang, S. Pitchuanchom, C. Boonyarat, C. Hahnvajanawong and C. Yenjai, Eur. J. Med. Chem., 45, 3794 (2010).
T. Thongthoom, P. Promsuwan and C. Yenjai, Eur. J. Med. Chem., 46, 3755 (2011).
C. Yenjai, S. Sripontan, P. Sriprajun, P. Kittakoop, A. Jintasirikul, M. Tanticharoen and Y. Thebtaranonth, Planta Med., 66, 277 (2000).
U. Songsiang, T. Thongthoom, C. Boonyarat and C. Yenjai, J. Nat. Prod., 74, 208 (2011).
T. Thongthoom, U. Songsiang, C. Phaosiri and C. Yenjai, Arch. Pharm. Res., 33, 675 (2010).
K. Noipha, T. Thongthoom, U. Songsiang, C. Boonyarat and C. Yenjai, Diabetes Res. Clin. Pract., 90, e67 (2010).
T. Nakamura, N. Kodama, Y. Arai, T. Kumamoto, Y. Higuchi, C. Chaichantipyuth, T. Ishikawa, K. Ueno and S. Yano, J. Nat. Med., 63, 21 (2009).
Z. Luo, L. Boonyaratanakornkit, C.T. Che, C.A.J. Erdelmeier, H.H.S. Fong and N.R. Farnsworth, J. Nat. Prod., 6, 1161 (1986).
Y.Y. Chan, C.H. Li, Y.C. Shen and T.S. Wu, Chem. Pharm. Bull., 58, 61 (2010).
A. Murakami, G. Gao, M. Omura, M. Yano, C. Ito, H. Furukawa, D. Takahashi, K. Koshimizu and H. Ohigashi, Bioorg. Med. Chem. Lett., 10, 59 (2000).
E. Melliou, P. Magiatis, S. Mitaku,A. Skaltsounis, E. Chinou and I. Chinou, J. Nat. Prod., 68, 78 (2005).
J.O. Brien, I. Wilson, T. Orton and F. Pognan, Eur. J. Biochem., 267, 5421 (2000).
L. Hunt, M. Jordan, M. De Jesus and F.M. Wurm, Biotechnol. Bioeng., 65, 201 (1999)