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Vol. 25 No. 7 (2013): Vol 25 Issue 7

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Optimization and Antifungal Activity of Amide Analogues

https://doi.org/10.14233/ajchem.2013.13895
Hui Feng
School of Bioengineering, Xihua University, Chengdu 610039, P.R. China
Li Leng
School of Life Science, Sichuan University, Chengdu 610064, P.R. China
Jia Liu
School of Bioengineering, Xihua University, Chengdu 610039, P.R. China
Yuanmou Tang
School of Bioengineering, Xihua University, Chengdu 610039, P.R. China
Pengcheng Tang
School of Bioengineering, Xihua University, Chengdu 610039, P.R. China
Chixiang Zhang
School of Bioengineering, Xihua University, Chengdu 610039, P.R. China
Xioarong Tang
School of Bioengineering, Xihua University, Chengdu 610039, P.R. China
Shirong Jiao
School of Bioengineering, Xihua University, Chengdu 610039, P.R. China

Corresponding Author(s) : Shirong Jiao

huif2010@163.com

Asian Journal of Chemistry, Vol. 25 No. 7 (2013): Vol 25 Issue 7

Abstract

Using salicylic acid as a lead compound, a series of its analogues (compounds 1-16) were designed and synthesized. Their activity of anti-pathogenic fungi of plants has been evaluated in the laboratory. The results showed that these compounds had certain antifungal activity against Sclerotinia sclerotiorum and Bipolaris maydis (Nisikado et Miyake) Shoem. Among them, the inhibition of growth for 2-(3-fluorophenylcarbamoyl)phenyl acetate (1) and 2-(3-chlorophenylcarbamoyl)phenyl acetate (2) reached 91.1 %, 92.8 % and 90.1 %, 90.1 % at a concentration of 100 mg L-1, respectively.

Keywords

Antifungal activity Amide analogues Synthesis
Feng, H., Leng, L., Liu, J., Tang, Y., Tang, P., Zhang, C., … Jiao, S. (2013). Optimization and Antifungal Activity of Amide Analogues. Asian Journal of Chemistry, 25(7), 4029–4031. https://doi.org/10.14233/ajchem.2013.13895
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