Synthesis of Stimuli Responsive Graft Triblock Polymers via Combination of Reversible Addition-Fragmentation Chain Transfer Polymerization and Ring Opening Polymerization

Chenglin Wu; Anguo Ying; Shibin Ren

doi:10.14233/ajchem.2013.13699

Issue

Vol. 25 No. 6 (2013): Vol 25 Issue 6

Issue Published : December 26, 2012

This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis of Stimuli Responsive Graft Triblock Polymers via Combination of Reversible Addition-Fragmentation Chain Transfer Polymerization and Ring Opening Polymerization

https://doi.org/10.14233/ajchem.2013.13699

Chenglin Wu

School of Pharmaceutical and Chemical Engineering, Taizhou University, Taizhou 317000, Zhejiang Province, P.R. China

Anguo Ying

School of Pharmaceutical and Chemical Engineering, Taizhou University, Taizhou 317000, Zhejiang Province, P.R. China

Shibin Ren

School of Pharmaceutical and Chemical Engineering, Taizhou University, Taizhou 317000, Zhejiang Province, P.R. China

Corresponding Author(s) : Chenglin Wu

clwu@tzc.edu.cn

Asian Journal of Chemistry, Vol. 25 No. 6 (2013): Vol 25 Issue 6
Article Published : January 9, 2013

Abstract

A well-defined triblock copolymer, poly(ethylene glycol)-b-poly(2-hydroxyethyl methacrylate-g-lactide)-b-poly(N-isopropylacrylamide) [PEG-P(HEMA-PLA)-PNIPAM], containing a biodegradable PLA block and a thermo-sensitive PNIPAM block, was synthesized by a combination of ring opening polymerization (ROP) and reversible addition-fragmentation chain transfer polymerization (RAFT). The copolymer could self-assemble into core-shell micelles with PLA block as the core and PEG/PNIPAM blocks as the mixed shell at ambient temperature. With increasing temperature, the micelles converted into the core-shell-corona (CSC) structure because of the collapsed PNIPAM block. Dynamic light scattering shows that the hydrodynamic diameter (D_h) of the micelles is about 140 nm at low temperature (25 ºC) and 110 nm at high temperature (45 ºC).

Keywords

Stimuli-responsive polymer Reversible addition-fragmentation chain transfer polymerization Ring opening polymerization Core-shell-corona structure Graft copolymers

Wu, C., Ying, A., & Ren, S. (2013). Synthesis of Stimuli Responsive Graft Triblock Polymers via Combination of Reversible Addition-Fragmentation Chain Transfer Polymerization and Ring Opening Polymerization. Asian Journal of Chemistry, 25(6), 3344–3348. https://doi.org/10.14233/ajchem.2013.13699

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R. Haag, Angew. Chem. Int. Ed., 43, 278 (2004).

A. Rosler, G.W.M. Vandermeulen and H.A. Klok, Adv. Drug. Deliv. Rev., 53, 95 (2001).

Y. Kakizawa and K. Kataoka, Adv. Drug. Deliv. Rev., 54, 203 (2002).

R. Duncan, Nat. Rev. Drug. Discov., 2, 347 (2003).

Z. Jiao, X. Wang and Z.M. Chen, Asian J. Chem., 25, 1765 (2013).

H.G. Schild, Prog. Polym. Sci., 17, 163 (1992).

R. Nojima, T. Sato, X.P. Qiu and F.M. Winnik, Macromolecules, 41, 292 (2008).

P. Kujawa, F. Tanaka and F.M. Winnik, Macromolecules, 39, 3048 (2006).

T. Maeda, M. Takenouchi, K. Yamamoto and T. Aoyagi,Biomacromolecules, 7, 2230 (2006).

H. Wei, S.X. Cheng, X.Z. Zhang and R.X. Zhuo, Prog. Polym. Sci., 34, 893 (2009).

C. Chang, H. Wei, C.Y. Quan, Y.Y. Li, J. Liu, Z.C. Wang, S.X. Cheng, X.Z. Zhang and R.X. Zhuo, J. Polym. Sci. A: Polym. Chem., 46, 3048 (2008).

J.L. Zhu, X.Z. Zhang, H. Cheng, Y.Y. Li, S.X. Cheng and R.X. Zhuo, J. Polym. Sci. A: Polym. Chem., 45, 5354 (2007).

G.Y. Li, L.Q. Shi, R.J. Ma, Y.L. An and N. Huang, Angew. Chem. Int. Ed., 45, 4959 (2006).

C.L. Wu, R.J. Ma, H. He, L.Z. Zhao, H.J. Gao, Y.L. An and L.Q. Shi, Macromol. Biosci., 9, 1185 (2009).

C.L. Lo, C.K. Huang, K.M. Lin and G.H. Hsiue, Biomaterials, 28, 1225 (2007).

N. Willet, F. Gohy, L. Auvray, S. Varshney, R. Jerome and B. Leyh, Langmuir, 24, 3009 (2008).

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F.T. Liu and A. Eisenberg, J. Am. Chem. Soc., 125, 15059 (2003).

J.W. Hu, G.J. Liu and G. Nijkang, J. Am. Chem. Soc., 130, 3236 (2008).

R. Stoenescu, A. Graff and W.M. Meier, Macromol. Biosci., 4, 930 (2004).

A. Walther, P.E. Millard, A.S. Goldmann, T.M. Lovestead, F. Schacher, C. Barner-Kowollik and A.H.E. Muller, Macromolecules, 41, 8608 (2008).

R.K. Bai, Y.Z. You and C.Y. Pan, Polym. Int., 49, 898 (2000).

D.W. Lim, S.H. Choi and T.G. Park, Macromol. Rapid. Commun., 21, 464 (2000).

J.Y. Zhang, X. Jiang, Y.F. Zhang, Y.T. Li and S.Y. Liu, Macromolecules, 40, 9125 (2007).

C. Schilli, M.G. Lanzendorfer and A. Muller, Macromolecules, 35, 6819 (2002).

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M. Le Hellaye, C. Lefay, T.P. Davis, M.H. Stenzel and C. BarnerKowollik, J. Polym. Sci. A: Polym. Chem., 46, 3058 (2008).

M. Teodorescu and K. Matyjaszewski, Macromolecules, 32, 4826 (1999).

C. Deng, X.S. Chen, H.J. Hu, J. Sun, T.C. Lu and X.B. Jing, Polymer, 48, 139 (2007).

Issue

Vol. 25 No. 6 (2013): Vol 25 Issue 6

Synthesis of Stimuli Responsive Graft Triblock Polymers via Combination of Reversible Addition-Fragmentation Chain Transfer Polymerization and Ring Opening Polymerization

Corresponding Author(s) : Chenglin Wu

Abstract

Keywords

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