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Vol. 25 No. 6 (2013): Vol 25 Issue 6

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Synthesis and Bioactivity of Furoxan-Based Nitric Oxide-Releasing Colchicine Derivatives as Anticancer Agents

https://doi.org/10.14233/ajchem.2013.13635
Li Hong Shen
Handan Key Laboratory of Organic Small Molecule Materials, Handan College, Handan 056005, P.R. China
Sheng Li Wang
Handan Key Laboratory of Organic Small Molecule Materials, Handan College, Handan 056005, P.R. China
Hong Yu Li
Handan Key Laboratory of Organic Small Molecule Materials, Handan College, Handan 056005, P.R. China
Yi Sheng Lai
Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009, P.R. China
Li Jie Liu
Hebei Yiling Medicine Corporation Ltd, Shijiazhuang 050035, P.R. China

Corresponding Author(s) : Li Hong Shen

latishen@sohu.com

Asian Journal of Chemistry, Vol. 25 No. 6 (2013): Vol 25 Issue 6

Abstract

A series of novel nitric oxide-donating colchicine derivatives (9a-j) were synthesized by coupling furoxan with N-methyl colchiceinamide through an appropriate spacer arm and their cytotoxicity against four human cancer cell lines in vitro were evaluated by MTT method. It was found that many of the derivatives displayed significant activity, particularly, compound 9f showed more potent cytotoxic activities than colchicine.

Keywords

Nitric oxide-donating colchicine derivatives N-Methyl colchiceinamide Furoxan Cytotoxicity
Hong Shen, L., Li Wang, S., Yu Li, H., Sheng Lai, Y., & Jie Liu, L. (2013). Synthesis and Bioactivity of Furoxan-Based Nitric Oxide-Releasing Colchicine Derivatives as Anticancer Agents. Asian Journal of Chemistry, 25(6), 3294–3296. https://doi.org/10.14233/ajchem.2013.13635
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