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Vol. 25 No. 6 (2013): Vol 25 Issue 6

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Design and Synthesis of Naphthol Derivative Using Three Components System and Its Relation with Physicochemical Parameters log P and p

https://doi.org/10.14233/ajchem.2013.13905
L. Figueroa-Valverde
Laboratory of Pharmaco-Chemistry, Faculty of Chemical Biological Sciences, University Autonomic of Campeche, Av. Agustín Melgar s/n, Col., Buenavista C.P. 24039 Campeche Cam., México
F. Diaz-Cedillo
Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional, Prol. Carpio y Plan de Ayala s/n Col. Santo Tomas, D.F. C.P. 11340, México
E. García-Cervera
Laboratory of Pharmaco-Chemistry, Faculty of Chemical Biological Sciences, University Autonomic of Campeche, Av. Agustín Melgar s/n, Col., Buenavista C.P. 24039 Campeche Cam., México
E. Pool Gómez
Laboratory of Pharmaco-Chemistry, Faculty of Chemical Biological Sciences, University Autonomic of Campeche, Av. Agustín Melgar s/n, Col., Buenavista C.P. 24039 Campeche Cam., México
Johany Cordova-Vazquez
Laboratory of Pharmaco-Chemistry, Faculty of Chemical Biological Sciences, University Autonomic of Campeche, Av. Agustín Melgar s/n, Col., Buenavista C.P. 24039 Campeche Cam., México

Corresponding Author(s) : L. Figueroa-Valverde

lauro_1999@yahoo.com

Asian Journal of Chemistry, Vol. 25 No. 6 (2013): Vol 25 Issue 6

Abstract

A naphthol derivative was synthesized using the three-component system (b-naphthol, benzaldehyde and N-(2-aminoethyl)-4-hydroxybenzamide) and characterized by spectral analyses. In order to characterize the structural and chemical requirements of naphthol derivative, some parameters such as log P and p were evaluated. The results showed an increase in the values of log P and p for the compound 4 in comparison with 1, 2 and 3. These data indicate a high degree of lipophilicity and steric impediment for compound 4 in comparison with 1, 2 and 3.

Keywords

Naphthol Derivatives Synthesis
Figueroa-Valverde, L., Diaz-Cedillo , F., García-Cervera, E., Pool Gómez, E., & Cordova-Vazquez, J. (2013). Design and Synthesis of Naphthol Derivative Using Three Components System and Its Relation with Physicochemical Parameters log P and p. Asian Journal of Chemistry, 25(6), 3421–3423. https://doi.org/10.14233/ajchem.2013.13905
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