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Vol. 25 No. 6 (2013): Vol 25 Issue 6

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Colourimetric Estimation of Escitalopram Oxalate in Formulation by Ion Association Complex with Methyl Orange

https://doi.org/10.14233/ajchem.2013.13885
Pushparaj Hemalatha
Department of Chemical Engineering, Hanseo University, 360 Daegok-ri, Haemi-myun, Seosan-si 356 706, Chungcheongnam-do, South Korea ; Korea Carbon Capture and Sequestration R and D Centre, 360 Daegok-ri, Haemi-myun, Seosan-si 356 706, Chungcheongnam-do, South Korea
Mani Ganesh
Department of Chemical Engineering, Hanseo University, 360 Daegok-ri, Haemi-myun, Seosan-si 356 706, Chungcheongnam-do, South Korea ; Korea Carbon Capture and Sequestration R and D Centre, 360 Daegok-ri, Haemi-myun, Seosan-si 356 706, Chungcheongnam-do, South Korea
Mei Mei Peng
Department of Chemical Engineering, Hanseo University, 360 Daegok-ri, Haemi-myun, Seosan-si 356 706, Chungcheongnam-do, South Korea ; Korea Carbon Capture and Sequestration R and D Centre, 360 Daegok-ri, Haemi-myun, Seosan-si 356 706, Chungcheongnam-do, South Korea
Hyun Tae Jang
Department of Chemical Engineering, Hanseo University, 360 Daegok-ri, Haemi-myun, Seosan-si 356 706, Chungcheongnam-do, South Korea ; Korea Carbon Capture and Sequestration R and D Centre, 360 Daegok-ri, Haemi-myun, Seosan-si 356 706, Chungcheongnam-do, South Korea

Corresponding Author(s) : Hyun Tae Jang

htjang@hanseo.ac.kr

Asian Journal of Chemistry, Vol. 25 No. 6 (2013): Vol 25 Issue 6

Abstract

A new and fully validated ion pair spectrophotometric method has been developed for estimation for escitalopram oxalate in bulk and tablet formulation using acidic methyl orange dye as an ion associating agent in the absence of buffer. The developed method is sensitive and specific for the intended purpose of estimation. Ion association complex of escitalopram oxalate and methyl orange obeys Beer's law in the range of 4-24 μg mL-1 of escitalopram oxalate with a correlation coefficient of 0.9987. Accuracy, precision, stability, LOD, LOQ, interference, robustness and ruggedness were studied for validation of the method. The results recovery with low % RSD of 0.88-1.02; precision is also good in agreement with validation limits. The method developed was successfully applied for the estimation of the escitalopram oxalate in its formulation.

Keywords

Escitalopram Methyl orange Ion association Spectrophotometric
Hemalatha, P., Ganesh, M., Mei Peng, M., & Tae Jang, H. (2013). Colourimetric Estimation of Escitalopram Oxalate in Formulation by Ion Association Complex with Methyl Orange. Asian Journal of Chemistry, 25(6), 3410–3414. https://doi.org/10.14233/ajchem.2013.13885
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