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Influence of Phosphorylated Peptides on the Growth of Hydroxyapatite
Corresponding Author(s) : Yuanyuan Zhou
Asian Journal of Chemistry,
Vol. 25 No. 5 (2013): Vol 25 Issue 5
Abstract
Phosphorylated peptides, having varying degrees of substitution, were soaked in a simulated body fluid (SBF) solution in order to investigate their ability to induce the formation of a calcium phosphate layer. We had dealt with the effect of phosphorylated peptides and peptides onto synthetic hydroxyapatite by separately considering their influence when they were present in the 1.5SBF solutions. Mineralization was assessed by transmission electron microscopy and FT-IR spectromete. It was demonstrated that the phosphate introduced on the chain of peptides could promoted the higher extent of mineralization and exhibited a guiding role in the mineralization of hydroxyapatite. This was suggested that the phosphate moieties in the peptides were important for its function as a mediator of biomineralization.
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- F. Miyaji, M. Iwai, T. Kokubo and T. Nakamura, J. Mater. Sci. Mater. Med., 9, 61 (1998).
- X.K. Li and J. Chang, J. Biomed. Mater. Res., 85, 2 (2008)
References
G. He, A. Ramachandran, T. Dahl and S. George, J. Biol. Chem., 280, 39 (2005).
W. Schneiders and A. Reinstorf, Bone, 40, 4 (2007).
J.H. Bradt and M. Mertig, J. Mater. Chem., 11, 10 (1999).
J.V. Garcia-Ramos and P. Carmona, J. Colloid Interf. Sci., 83, 479 (1981).
F. Miyaji, M. Iwai, T. Kokubo and T. Nakamura, J. Mater. Sci. Mater. Med., 9, 61 (1998).
X.K. Li and J. Chang, J. Biomed. Mater. Res., 85, 2 (2008)