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Vol. 25 No. 5 (2013): Vol 25 Issue 5

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Phosalone Toxicity on Liver and Pancreas: Role of Vitamins E and C

https://doi.org/10.14233/ajchem.2013.13487
Hilmi Demirin
Department of Biochemistry, School of Medicine, University of Duzce, 81620 Duzce, Turkey
Osman Gokalp
Department of Pharmacology, School of Medicine, University of Dicle, 21280 Diyarbakir, Turkey
Ertugrul Kaya
Department of Pharmacology, School of Medicine, University of Duzce, 81620 Duzce, Turkey
Bora Buyukvanli
Department of Physiology, School of Medicine, University of Suleyman Demirel, Isparta, Turkeyartment of Physiology, School of Medicine, University of Suleyman Demirel, Isparta, Turkey
Gokhan Cesur
Department of Physiology, School of Medicine, University of Suleyman Demirel, Isparta, Turkey
Aybars Ozkan
Department of Pediatric Surgery, School of Medicine, University of Duzce, 81620 Duzce, Turkey
Murat Kaya
Department of Pediatric Surgery, School of Medicine, University of Duzce, 81620 Duzce, Turkey

Corresponding Author(s) : Hilmi Demirin

hilmidemirin@hotmail.com

Asian Journal of Chemistry, Vol. 25 No. 5 (2013): Vol 25 Issue 5

Abstract

Phosalone (6-chloro-3-[diethoxyphosphinothioylsulfanylmethyl]-1,3-benzoxazol-2-one) is one of the most commonly used organophosphorus pesticides in the pest control of crops. Subchronic phosalone exposure was evaluated for its effects on the serum activities of some enzymes concerning hepatic and pancreatic damage including aspartate aminotransferase (AST), alanine aminotransferase (ALT), glutamyltransferase (GGT), lactate dehydrogenase (LDH), alkaline phosphatase (ALP), cholinesterase (ChE); and finally protective effects of combination of vitamins E and C in 24 wistar-albino rats. Experimental groups were as follows: control group (n = 8); a group treated with 120 mg/kg body weight phosalone (P group, n = 8); and a group treated with 120 mg/kg body weight phosalone + vitamin E + vitamin C (P+V group, n = 8). The P and P+V groups were treated orally with phosalone on 5 days a week for 4 weeks. The serum activities of the above mentioned enzymes were analyzed. In the samples, phosalone significantly increased the activities of ALT, LDH and decreased ChE (p < 0.05). However no significant change was detected for the remainder enzymes (p > 0.05). In the P+V group, ALT and LDH activities were significantly increased and ChE decreased (p < 0.05). It is concluded that subchronic phosalone causes rat liver damage to an extent, which is somewhat reflected on the liver enzymes. Furthermore, a combination of vitamins E and C can reduce the toxic effects of phosalone on liver tissue of rats.

Keywords

Phosalone Toxicity Liver Pancreas Enzymes
Demirin, H., Gokalp, O., Kaya, E., Buyukvanli, B., Cesur, G., Ozkan, A., & Kaya, M. (2012). Phosalone Toxicity on Liver and Pancreas: Role of Vitamins E and C. Asian Journal of Chemistry, 25(5), 2589–2592. https://doi.org/10.14233/ajchem.2013.13487
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