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Chemical Analysis of Burdock Root Constituents
Corresponding Author(s) : Chunbo Wang
Asian Journal of Chemistry,
Vol. 25 No. 5 (2013): Vol 25 Issue 5
Abstract
An ethanolic solution of extracted burdock root was concentrated, suspended by water and extracted by petroleum ether, chloroform, ethyl acetate and n-butanol. Then, the solution was purified by silica gel, Sephadex LH-20 and C18 column chromatography to obtain 17 compounds. Nine structures of compounds, identified according to physical and chemical properties using IR, UV, ESIMS, 1H NMR, 13C NMR and other methods, include 3 petroleum ethers (b-sitosterol, oleanolic acid, ursolic acid), 4 chloroforms (b-sitosterol, daucosterol, syringaresinol, ethyl-b-D-pyran fruit glycosides), 1 ethyl acetate (1,5-O-two caffeoylquinic acid) and n-butanol parts (succinic acid and 5-hydroxy maltol). Oleanolic acid, ursolic acid, clove lignans, ethyl-b-D-pyran fruit glycoside, succinic acid and 5-hydroxy maltol were first isolated from burdock.
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References
F.B. Holetz, G.L. Pessini, N.R. Sanches, D.A. Cortez, C.V. Nakamura and B.P. Filho, Mem. Inst. Oswaldo Cruz., 97, 1027 (2002).
M. Takasugi, S. Kawashima and N. Katsui, Phytochemistry, 26, 2957 (1987).
L.C. Chiang, W. Chiang, M.Y. Chang, L.T. Ng and C.C. Lin, Antiviral Res., 55, 53 (2002).
K. Miyamoto, M. Nomura, M. Sasakura, E. Matsui, R. Koshiura, T. Murayama, T. Furukawa, T. Hatano, T. Yoshida and T. Okuda, Cancer Res., 84, 99 (1993).
C. Tamayo, M.A. Richardson, S. Diamond and I. Skoda, Phytother. Res., 14, 1 (2000).
S.C. Lin, C.H. Lin, C.C. Lin, Y.H. Lin, C.F. Chen, I.C. Chen and L.Y. Wang, J. Biomed. Sci., 9, 401 (2002).
M. Mitsuo, Y. Nobuo and T. Katsuya, J. Oleo. Sci., 54, 589 (2005).
F.D. Wang, G.H. Feng and K.S. Chen, Postharvest Biol. Technol., 52, 110 (2009).
H. Kojinna and H. Ogura, Phytochemistry, 25, 729 (1986).
D.T. Coxon and J.W. Wells, Phytochemistry, 19, 1247 (1980).
M.M. Badawi, S.S. Handa, A.D. Kinghorn, G.A. Cordell and N.R. Farnsworth, J. Pharm. Sci., 72, 1285 (1983).
H.X. Kuang, R. Kasai, K. Ohtani, Z.S. Liu, C.S. Yuan and O. Tanaka, Chem. Pharm. Bull., 37, 2232 (1989).
Z.J. Jia, Y. Zhao and R.X. Tan, J. Nat. Prod., 56, 494 (1993).
Y. Shinoda, M. Murata, S. Homma and H. Komura, Biosci. Biotechnol. Biochem., 68, 529 (2004)